Pregn-4-ene-3,20-dione,11-hydroxy-, (11α)-

Modify Date: 2025-08-25 21:26:23

Pregn-4-ene-3,20-dione,11-hydroxy-, (11α)- Structure
Pregn-4-ene-3,20-dione,11-hydroxy-, (11α)- structure
 Common Name Pregn-4-ene-3,20-dione,11-hydroxy-, (11α)-
CAS Number 80-75-1 Molecular Weight 330.46
Density 1.15 g/cm3 Boiling Point 487.4ºC at 760 mmHg
Molecular Formula C21H30O3 Melting Point 165-166ºC(lit.)
MSDS N/A Flash Point 262.7ºC

 Use of Pregn-4-ene-3,20-dione,11-hydroxy-, (11α)-


11alpha-Hydroxyprogesterone is the inactive analogue of 11beta-Hydroxyprogesterone (HY-N2337), and can be used as an experimental control. 11beta-Hydroxyprogesterone is a potent inhibitors of 11β-Hydroxysteroid dehydrogenase; also activates human mineralocorticoid receptor in COS-7 cells with an ED50 of 10 nM.

 Names

Name 11α-hydroxyprogesterone
Synonym More Synonyms

  Biological Activity

Description 11alpha-Hydroxyprogesterone is the inactive analogue of 11beta-Hydroxyprogesterone (HY-N2337), and can be used as an experimental control. 11beta-Hydroxyprogesterone is a potent inhibitors of 11β-Hydroxysteroid dehydrogenase; also activates human mineralocorticoid receptor in COS-7 cells with an ED50 of 10 nM.
Related Catalog
References

[1]. Rafestin-Oblin ME, et al. 11beta-hydroxyprogesterone acts as a mineralocorticoid agonist in stimulating Na+ absorption in mammalian principal cortical collecting duct cells. Mol Pharmacol. 2002 Dec;62(6):1306-13.  

[2]. Souness GW, et al. 11 alpha- and 11 beta-hydroxyprogesterone, potent inhibitors of 11 beta-hydroxysteroid dehydrogenase, possess hypertensinogenic activity in the rat. Hypertension. 1996 Mar;27(3 Pt 1):421-5.  

 Chemical & Physical Properties

Density 1.15 g/cm3
Boiling Point 487.4ºC at 760 mmHg
Melting Point 165-166ºC(lit.)
Molecular Formula C21H30O3
Molecular Weight 330.46
Flash Point 262.7ºC
Exact Mass 330.21900
PSA 54.37000
LogP 3.69430
Index of Refraction 1.557
Storage condition Refrigerator

 Safety Information

Safety Phrases S24/25
WGK Germany 3
RTECS TU5057000

 Synthetic Route

 Synonyms

11alpha-hydroxyprogesterone
HYDROXYPROGESTERONE,11A
DG 322B
11A-HYDROXYPROGESTERONE
EINECS 201-306-9
4-PREGNEN-11A-OL-3,20-DIONE
MFCD00003652
Progesterone,11alpha-hydroxy
Progesterone, 11.α.-hydroxy-
U 0384
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Chemsrc provides CAS#:80-75-1 MSDS, density, melting point, boiling point, structure, etc. Its name is Pregn-4-ene-3,20-dione,11-hydroxy-, (11α)->> amp version: Pregn-4-ene-3,20-dione,11-hydroxy-, (11α)-

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