Pregn-4-ene-3,20-dione,11-hydroxy-, (11α)-

Names

[ CAS No. ]:
80-75-1

[ Name ]:
Pregn-4-ene-3,20-dione,11-hydroxy-, (11α)-

[Synonym ]:
11alpha-hydroxyprogesterone
HYDROXYPROGESTERONE,11A
DG 322B
11A-HYDROXYPROGESTERONE
EINECS 201-306-9
4-PREGNEN-11A-OL-3,20-DIONE
MFCD00003652
Progesterone,11alpha-hydroxy
Progesterone, 11.α.-hydroxy-
U 0384

Biological Activity

[Description]:

11alpha-Hydroxyprogesterone is the inactive analogue of 11beta-Hydroxyprogesterone (HY-N2337), and can be used as an experimental control. 11beta-Hydroxyprogesterone is a potent inhibitors of 11β-Hydroxysteroid dehydrogenase; also activates human mineralocorticoid receptor in COS-7 cells with an ED50 of 10 nM.

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Others >> Others

[References]

[1]. Rafestin-Oblin ME, et al. 11beta-hydroxyprogesterone acts as a mineralocorticoid agonist in stimulating Na+ absorption in mammalian principal cortical collecting duct cells. Mol Pharmacol. 2002 Dec;62(6):1306-13.

[2]. Souness GW, et al. 11 alpha- and 11 beta-hydroxyprogesterone, potent inhibitors of 11 beta-hydroxysteroid dehydrogenase, possess hypertensinogenic activity in the rat. Hypertension. 1996 Mar;27(3 Pt 1):421-5.

Chemical & Physical Properties

[ Density]:
1.15 g/cm3

[ Boiling Point ]:
487.4ºC at 760 mmHg

[ Melting Point ]:
165-166ºC(lit.)

[ Molecular Formula ]:
C₂₁H₃₀O₃

[ Molecular Weight ]:
330.46

[ Flash Point ]:
262.7ºC

[ Exact Mass ]:
330.21900

[ PSA ]:
54.37000

[ LogP ]:
3.69430

[ Index of Refraction ]:
1.557

[ Storage condition ]:
Refrigerator

MSDS

Click to get detail MSDS

Safety Information

[ Safety Phrases ]:
S24/25

[ WGK Germany ]:
3

[ RTECS ]:
TU5057000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.