Lovastatin Diol Lactone

Modify Date: 2025-08-26 22:56:04

Lovastatin Diol Lactone structure	Common Name	Lovastatin Diol Lactone
	CAS Number	79952-42-4	Molecular Weight	320.423
	Density	1.2±0.1 g/cm3	Boiling Point	535.7±50.0 °C at 760 mmHg
	Molecular Formula	C₁₉H₂₈O₄	Melting Point	104-114 °C
	MSDS	N/A	Flash Point	191.2±23.6 °C

Use of Lovastatin Diol Lactone

Monacolin J is an inhibitor of cholesterol biosynthesis, and inhibits the activity of HMG-CoA reductase.

Name	monacolin J
Synonym	More Synonyms

Description	Monacolin J is an inhibitor of cholesterol biosynthesis, and inhibits the activity of HMG-CoA reductase.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> HMG-CoA Reductase (HMGCR) Research Areas >> Metabolic Disease
Target	HMG-CoA reductase[1]
In Vitro	Monacolin J is an inhibitor of cholesterol biosynthesis, and inhibits the activity of HMG-CoA reductase. Na salt of Monacolin J causes 50% inhibition on reductase at 1.2 μg/mL[1].
References	[1]. Endo A, et al. Monacolins J and L, new inhibitors of cholesterol biosynthesis produced by Monascus ruber. J Antibiot (Tokyo). 1985 Mar;38(3):420-2.

Density	1.2±0.1 g/cm3
Boiling Point	535.7±50.0 °C at 760 mmHg
Melting Point	104-114 °C
Molecular Formula	C₁₉H₂₈O₄
Molecular Weight	320.423
Flash Point	191.2±23.6 °C
Exact Mass	320.198761
PSA	66.76000
LogP	1.81
Vapour Pressure	0.0±3.2 mmHg at 25°C
Index of Refraction	1.558
InChIKey	ZDFOBOYQVYMVCW-IRUSZSJRSA-N
SMILES	CC1C=C2C=CC(C)C(CCC3CC(O)CC(=O)O3)C2C(O)C1

Hazard Codes	Xi

Antibiotic MB 530A

(4R,6R)-4-Hydroxy-6-{2-[(1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydro-1-naphthalenyl]ethyl}tetrahydro-2H-pyran-2-one

2H-Pyran-2-one, 6-[2-[(1S,2S,6R,8S,8aR)-1,2,6,7,8,8a-hexahydro-8-hydroxy-2,6-dimethyl-1-naphthalenyl]ethyl]tetrahydro-4-hydroxy-, (4R,6R)-

Monacolin J

(4R,6R)-6-[2-[(1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]ethyl]-4-hydroxyoxan-2-one

Lovastatin diol lactone

Simvastatin EP Impurity H

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