DM3-SMe
Modify Date: 2025-08-20 12:53:19
DM3-SMe structure
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Common Name | DM3-SMe | ||
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| CAS Number | 796073-70-6 | Molecular Weight | 812.43200 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C38H54ClN3O10S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of DM3-SMeDM3-SMe is a maytansine derivative and a tubulin inhibitor, and is a cytotoxic moiety of antibody-drug conjugates (ADCs), which can be linked to antibody through disulfide bond or stable thioether bond. DM3-SMe shows highly cytotoxic activity in vitro with an IC50 of 0.0011 nM[1][2]. |
| Name | N2'-deacetyl-N2'-[4-(R,S)-(methyldithio)-1-oxopentyl]maytansine |
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| Description | DM3-SMe is a maytansine derivative and a tubulin inhibitor, and is a cytotoxic moiety of antibody-drug conjugates (ADCs), which can be linked to antibody through disulfide bond or stable thioether bond. DM3-SMe shows highly cytotoxic activity in vitro with an IC50 of 0.0011 nM[1][2]. |
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| Related Catalog | |
| Target |
Maytansinoids |
| References |
[2]. Yuliang Zhaoet al. Biomedical Nanomaterials. 2016-Science. |
| Molecular Formula | C38H54ClN3O10S2 |
|---|---|
| Molecular Weight | 812.43200 |
| Exact Mass | 811.29400 |
| PSA | 207.07000 |
| LogP | 6.08820 |