DC41SMe

Modify Date: 2024-01-09 20:41:17

DC41SMe Structure
DC41SMe structure
Common Name DC41SMe
CAS Number 1354787-71-5 Molecular Weight 726.31
Density N/A Boiling Point N/A
Molecular Formula C38H36ClN5O4S2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of DC41SMe


DC41-SMe is a DC1 derivative, shows cytotoxicity in Ramos, Namalwa, and HL60/s cells with IC50s ranging from 18-25 pM. DC1, a simplified analogue of CC-1065, is an antibody conjugate of cytotoxic DNA alkylators for the targeted treatment of cancer[1][2].

 Names

Name DC41-SMe

 DC41SMe Biological Activity

Description DC41-SMe is a DC1 derivative, shows cytotoxicity in Ramos, Namalwa, and HL60/s cells with IC50s ranging from 18-25 pM. DC1, a simplified analogue of CC-1065, is an antibody conjugate of cytotoxic DNA alkylators for the targeted treatment of cancer[1][2].
Related Catalog
References

[1]. Zhao RY, et al. Synthesis and biological evaluation of antibody conjugates of phosphate prodrugs of cytotoxic DNA alkylators for the targeted treatment of cancer. J Med Chem. 2012 Jan 26;55(2):766-82.

[2]. Kovtun YV, et al. Antibody-drug conjugates designed to eradicate tumors with homogeneous and heterogeneous expression of the target antigen. Cancer Res. 2006 Mar 15;66(6):3214-21.

 Chemical & Physical Properties

Molecular Formula C38H36ClN5O4S2
Molecular Weight 726.31
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