DM4-SMe

Modify Date: 2025-08-25 14:39:42

DM4-SMe structure	Common Name	DM4-SMe
	CAS Number	796073-68-2	Molecular Weight	826.45900
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₉H₅₆ClN₃O₁₀S₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of DM4-SMe

DM4-SMe is a metabolite of antibody-maytansin conjugates (AMCs) and a tubulin inhibitor, and also a cytotoxic moiety of antibody-drug conjugates (ADCs), which can be linked to antibody through disulfide bond or stable thioether bond. DM4-SMe inhibits KB cells with an IC50 of 0.026 nM[1][2].

Name	N2'-deacetyl-N2'-[4-methyl-4-(methyldithio)-1-oxopentyl]maytansine

Description	DM4-SMe is a metabolite of antibody-maytansin conjugates (AMCs) and a tubulin inhibitor, and also a cytotoxic moiety of antibody-drug conjugates (ADCs), which can be linked to antibody through disulfide bond or stable thioether bond. DM4-SMe inhibits KB cells with an IC50 of 0.026 nM[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin
Target	Maytansinoids
References	[1]. Widdison W, et al. Metabolites of antibody-maytansinoid conjugates: characteristics and in vitro potencies. Mol Pharm. 2015 Jun 1;12(6):1762-73. [2]. Chen H, et al. Tubulin Inhibitor-Based Antibody-Drug Conjugates for Cancer Therapy. Molecules. 2017 Aug 1;22(8).

Molecular Formula	C₃₉H₅₆ClN₃O₁₀S₂
Molecular Weight	826.45900
Exact Mass	825.31000
PSA	207.07000
LogP	6.47830

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: DM4-Sme
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Purity: 98.0%
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DM4-SMe

Use of DM4-SMe

Names

DM4-SMe Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.