Fosfomycin tromethamine

Modify Date: 2025-08-20 09:09:03

Fosfomycin tromethamine structure	Common Name	Fosfomycin tromethamine
	CAS Number	78964-85-9	Molecular Weight	259.194
	Density	N/A	Boiling Point	357ºC at 760 mmHg
	Molecular Formula	C₇H₁₈NO₇P	Melting Point	N/A
	MSDS	N/A	Flash Point	169.7ºC

Use of Fosfomycin tromethamine

Fosfomycin tromethamine (MK-0955 tromethamine) is a blood-brain barrier penetrating, broad-spectrum antibiotic by irreversibly inhibiting an early stage in cell wall synthesis. Fosfomycin tromethamine shows both in vivo and in vitro activity against a wide range of bacteria, including multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) bacteria[1].

Name	Fosfomycin tromethamine
Synonym	More Synonyms

Description	Fosfomycin tromethamine (MK-0955 tromethamine) is a blood-brain barrier penetrating, broad-spectrum antibiotic by irreversibly inhibiting an early stage in cell wall synthesis. Fosfomycin tromethamine shows both in vivo and in vitro activity against a wide range of bacteria, including multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) bacteria[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
References	[1]. Dijkmans AC, et al. Fosfomycin: Pharmacological, Clinical and Future Perspectives. Antibiotics (Basel). 2017 Oct 31;6(4). pii: E24.

Boiling Point	357ºC at 760 mmHg
Molecular Formula	C₇H₁₈NO₇P
Molecular Weight	259.194
Flash Point	169.7ºC
Exact Mass	259.082092
PSA	166.58000
Water Solubility	Very soluble in water, slightly soluble in ethanol (96 per cent) and in methanol, practically insoluble in acetone.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SZ9570000

CAS REGISTRY NUMBER :: 78964-85-9

LAST UPDATED :: 199403

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C4-H11-N-O3.C3-H7-O4-P

MOLECULAR WEIGHT :: 259.23

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 13,77,1988

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 13,77,1988

Hazard Codes	Xn
RIDADR	NONH for all modes of transport

2-amino-2-(hydr...

CAS#:855392-18-6

Disodium phosph...

CAS#:26016-99-9

Fosfomycin trom...

CAS#:78964-85-9

Literature: EP1762573 A1, ; Page/Page column 2 ;

Precursor 2
CAS#:855392-18-6 2-amino-2-(hydr... CAS#:26016-99-9 Disodium phosph...
DownStream 0

mono(2-ammonium-2-hydroxymethyl-1,3-propanediol) (2R,cis)-1,2-epoxypropyl-phosphonate

acide [(2R,3S)-3-méthyloxiran-2-yl]phosphonique - 2-amino-2-(hydroxyméthyl)propane-1,3-diol (1:1)

[(2R,3S)-3-Methyloxiran-2-yl]phosphonsäure--2-amino-2-(hydroxymethyl)propan-1,3-diol(1:1)

methyl)-1,3-propanediol(1:1)

(2R-cis)-(3-Methyloxiranyl)phosphonic Acid Compound with 2-Amino-2-(hydroxymethyl)propane-1,3-diol (1:1)

Phosphonic acid, [(2R,3S)-3-methyloxiranyl]-, compd. with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1)

fosfomycintrometamolsalt

FosfoMycin troMethaMine API

[(2R,3S)-3-Methyl-2-oxiranyl]phosphonic acid - 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1)

Tromethamine fosfosmycin

tromethamine-fosfomycin

(1R,2S)-(1,2-Epoxypropyl)phosphonic Acid Compound with 2-Amino-2-(hydroxymethyl)-1,3-propanediol (1:1)

FOSFOMYCIN TROMETHAMOL

monuril

z1282

FOSFOMYCIN TROMETAMOL

[(2R,3S)-3-Methyloxiran-2-yl]phosphonic acid - 2-amino-2-(hydroxymethyl)propane-1,3-diol (1:1)

1,3-Dihydroxy-2-(hydroxymethyl)propan-2-aminium hydrogen [(2R,3S)-3-methyloxiran-2-yl]phosphonate

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