78964-85-9

78964-85-9 structure

Name: Fosfomycin tromethamine
Chemical Name: Fosfomycin tromethamine
CAS Number: 78964-85-9
Molecular Formula: C₇H₁₈NO₇P
Molecular Weight: 259.194
Catalog: API Antibiotics Other antibiotics
Create Date: 2018-04-11 08:00:00
Modify Date: 2024-01-02 11:02:07
Fosfomycin tromethamine (MK-0955 tromethamine) is a blood-brain barrier penetrating, broad-spectrum antibiotic by irreversibly inhibiting an early stage in cell wall synthesis. Fosfomycin tromethamine shows both in vivo and in vitro activity against a wide range of bacteria, including multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) bacteria[1].

Name	Fosfomycin tromethamine
Synonyms	mono(2-ammonium-2-hydroxymethyl-1,3-propanediol) (2R,cis)-1,2-epoxypropyl-phosphonate acide [(2R,3S)-3-méthyloxiran-2-yl]phosphonique - 2-amino-2-(hydroxyméthyl)propane-1,3-diol (1:1) [(2R,3S)-3-Methyloxiran-2-yl]phosphonsäure--2-amino-2-(hydroxymethyl)propan-1,3-diol(1:1) methyl)-1,3-propanediol(1:1) (2R-cis)-(3-Methyloxiranyl)phosphonic Acid Compound with 2-Amino-2-(hydroxymethyl)propane-1,3-diol (1:1) Phosphonic acid, [(2R,3S)-3-methyloxiranyl]-, compd. with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1) fosfomycintrometamolsalt FosfoMycin troMethaMine API [(2R,3S)-3-Methyl-2-oxiranyl]phosphonic acid - 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1) Tromethamine fosfosmycin tromethamine-fosfomycin (1R,2S)-(1,2-Epoxypropyl)phosphonic Acid Compound with 2-Amino-2-(hydroxymethyl)-1,3-propanediol (1:1) FOSFOMYCIN TROMETHAMOL monuril z1282 FOSFOMYCIN TROMETAMOL [(2R,3S)-3-Methyloxiran-2-yl]phosphonic acid - 2-amino-2-(hydroxymethyl)propane-1,3-diol (1:1) 1,3-Dihydroxy-2-(hydroxymethyl)propan-2-aminium hydrogen [(2R,3S)-3-methyloxiran-2-yl]phosphonate

Description	Fosfomycin tromethamine (MK-0955 tromethamine) is a blood-brain barrier penetrating, broad-spectrum antibiotic by irreversibly inhibiting an early stage in cell wall synthesis. Fosfomycin tromethamine shows both in vivo and in vitro activity against a wide range of bacteria, including multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) bacteria[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
References	[1]. Dijkmans AC, et al. Fosfomycin: Pharmacological, Clinical and Future Perspectives. Antibiotics (Basel). 2017 Oct 31;6(4). pii: E24.

Boiling Point	357ºC at 760 mmHg
Molecular Formula	C₇H₁₈NO₇P
Molecular Weight	259.194
Flash Point	169.7ºC
Exact Mass	259.082092
PSA	166.58000
Water Solubility	Very soluble in water, slightly soluble in ethanol (96 per cent) and in methanol, practically insoluble in acetone.

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 13,77,1988

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 13,77,1988

Hazard Codes	Xn
RIDADR	NONH for all modes of transport

855392-18-6

26016-99-9

78964-85-9

Literature: EP1762573 A1, ; Page/Page column 2 ;

Precursor 2
855392-18-6 26016-99-9
DownStream 0