Description |
CRTh2 antagonist 2 is selective and potent CRTH2 antagonist extracted from patent US20140148470A1, compound Example 1, has an IC50 of ≤10 nM. CRTh2 antagonist 2 can be used in research of androgenic alopecia[1].
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Related Catalog |
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Target |
IC50: ≤10 nM (CRTh2)[1]
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In Vitro |
CRTH2 (chemoattractant receptor-homologous molecule expressed on Th2 cells) protein, also known as GPR44, is a G-protein coupled receptor (GPCR) which is amongst other ligands most strongly activated by prostaglandin D2 (PGD2). PGD2 is a product of prostaglandin D2 synthase (PTGDS)[1].
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References |
[1]. Andreas Schnapp, et al. Pyrimidine compounds for treating hairloss. US20140148470A1.
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