188936-12-1

188936-12-1 structure

Name: AP-1/NF-κB activation inhibitor 1
Chemical Name: AP-1/NF-κB activation inhibitor 1
CAS Number: 188936-12-1
Molecular Formula: C₁₃H₁₁F₃N₄O₄
Molecular Weight: 344.25
Catalog: Research Areas Inflammation/Immunology
Create Date: 2021-01-11 12:15:54
Modify Date: 2024-01-14 20:55:23
AP-1/NF-κB activation inhibitor 1 is a potent AP-1 and NF-κB mediated transcriptional activation inhibitor (IC50=1 μM), without blocking basal transcription driven by the β-actin promoter. AP-1/NF-κB activation inhibitor 1 has a similar inhibitory effect on the production of IL-2 and IL-8 levels in stimulated cells[1].

Name	AP-1/NF-κB activation inhibitor 1

Description	AP-1/NF-κB activation inhibitor 1 is a potent AP-1 and NF-κB mediated transcriptional activation inhibitor (IC50=1 μM), without blocking basal transcription driven by the β-actin promoter. AP-1/NF-κB activation inhibitor 1 has a similar inhibitory effect on the production of IL-2 and IL-8 levels in stimulated cells[1].
Related Catalog	Research Areas >> Inflammation/Immunology
References	[1]. Palanki MS, et al. Novel inhibitors of AP-1 and NF-kappaB mediated gene expression: structure-activity relationship studies of ethyl 4-[(3-methyl-2,5-dioxo(3-pyrrolinyl))amino]-2-(trifluoromethyl)++ +pyrimidi ne-5-carboxylate. Bioorg Med Chem Lett. 2000;10(15):1645-1648.

Molecular Formula	C₁₃H₁₁F₃N₄O₄
Molecular Weight	344.25