780763-95-3
780763-95-3 structure
- Name: AP-768
- Chemical Name: CRTh2 antagonist 2
- CAS Number: 780763-95-3
- Molecular Formula: C26H23ClN4O3
- Molecular Weight: 474.94
- Catalog: Signaling Pathways GPCR/G Protein Prostaglandin Receptor
- Create Date: 2020-06-01 08:14:32
- Modify Date: 2024-01-12 13:04:42
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CRTh2 antagonist 2 is selective and potent CRTH2 antagonist extracted from patent US20140148470A1, compound Example 1, has an IC50 of ≤10 nM. CRTh2 antagonist 2 can be used in research of androgenic alopecia[1].
| Name | CRTh2 antagonist 2 |
|---|
| Description | CRTh2 antagonist 2 is selective and potent CRTH2 antagonist extracted from patent US20140148470A1, compound Example 1, has an IC50 of ≤10 nM. CRTh2 antagonist 2 can be used in research of androgenic alopecia[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: ≤10 nM (CRTh2)[1] |
| In Vitro | CRTH2 (chemoattractant receptor-homologous molecule expressed on Th2 cells) protein, also known as GPR44, is a G-protein coupled receptor (GPCR) which is amongst other ligands most strongly activated by prostaglandin D2 (PGD2). PGD2 is a product of prostaglandin D2 synthase (PTGDS)[1]. |
| References |
[1]. Andreas Schnapp, et al. Pyrimidine compounds for treating hairloss. US20140148470A1. |
| Molecular Formula | C26H23ClN4O3 |
|---|---|
| Molecular Weight | 474.94 |