(RS)-AMPA

Modify Date: 2024-01-11 10:46:12

(RS)-AMPA structure	Common Name	(RS)-AMPA
	CAS Number	77521-29-0	Molecular Weight	186.165
	Density	1.5±0.1 g/cm3	Boiling Point	425.6±45.0 °C at 760 mmHg
	Molecular Formula	C₇H₁₀N₂O₄	Melting Point	240ºC
	MSDS	N/A	Flash Point	211.2±28.7 °C

Use of (RS)-AMPA

(RS)-AMPA ((±)-AMPA) is a glutamate analogue and a potent and selective excitatory neurotransmitter L-glutamic acid agonist. (RS)-AMPA does not interfere with binding sites for kainic acid or NMDA receptors[1][2].

Name	(r,s)-ampa
Synonym	More Synonyms

Description	(RS)-AMPA ((±)-AMPA) is a glutamate analogue and a potent and selective excitatory neurotransmitter L-glutamic acid agonist. (RS)-AMPA does not interfere with binding sites for kainic acid or NMDA receptors[1][2].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR
In Vitro	(RS)-AMPA (10-3-10-4 M) causes depolarizations of cultured rat spinal and brainstem neurones. The depolarization by (RS)-AMPA is clearly dose-dependent, although there is a great variability of effects between individual neurones. Application of (RS)-AMPA at 10-5 M produces only small depolarizations (3-7 mV), whereas at 10-4 M, the amplitudes of the depolarizations ranged from 4 to 33 mV. (RS)-AMPA also causes an increase of the discharge rate of spontaneously firing neurones or sometimes evoked a short burst of action potentials in silent cells. (RS)-AMPA exerts its depolarizing effects by activating glutamate/quisqualate receptors without affecting NMDA receptors[1].
References	[1]. Hösli L, et al. Effects of the glutamate analogue AMPA and its interaction with antagonists on cultured rat spinal and brain stem neurones. Neurosci Lett. 1983 Mar 28;36(1):59-62. [2]. Sommer B, et al. Flip and flop: a cell-specific functional switch in glutamate-operated channels of the CNS. Science. 1990 Sep 28;249(4976):1580-5.

Density	1.5±0.1 g/cm3
Boiling Point	425.6±45.0 °C at 760 mmHg
Melting Point	240ºC
Molecular Formula	C₇H₁₀N₂O₄
Molecular Weight	186.165
Flash Point	211.2±28.7 °C
Exact Mass	186.064056
PSA	109.58000
LogP	-0.44
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.579

WGK Germany	3

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DC Chemicals Limited
China
Product Name: (R,S)-AMPA
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: (RS)-3-AMINO-3-(3-PYRIDYL)-PROPIONICACID
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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