77521-29-0

77521-29-0 structure

Name: (RS)-AMPA
Chemical Name: (r,s)-ampa
CAS Number: 77521-29-0
Molecular Formula: C₇H₁₀N₂O₄
Molecular Weight: 186.165
Catalog: Signaling Pathways Membrane Transporter/Ion Channel iGluR
Create Date: 2016-06-02 02:10:46
Modify Date: 2024-01-11 10:46:12
(RS)-AMPA ((±)-AMPA) is a glutamate analogue and a potent and selective excitatory neurotransmitter L-glutamic acid agonist. (RS)-AMPA does not interfere with binding sites for kainic acid or NMDA receptors[1][2].

Name	(r,s)-ampa
Synonyms	ampa 3-(5-Méthyl-3-oxo-2,3-dihydro-1,2-oxazol-4-yl)alanine UNII:J090588E6X 2-Amino-3-(5-methyl-3-oxo-2,3-dihydro-1,2-oxazol-4-yl)propanoic acid 3-(5-Methyl-3-oxo-2,3-dihydro-1,2-oxazol-4-yl)alanine 3-(5-Methyl-3-oxo-2,3-dihydro-1,2-oxazol-4-yl)alanin ampa hbr 2-ammonio-3-(3-hydroxy-5-methyl-1,2-oxazol-4-yl)propanoate 4-Isoxazolepropanoic acid, α-amino-2,3-dihydro-5-methyl-3-oxo-

Description	(RS)-AMPA ((±)-AMPA) is a glutamate analogue and a potent and selective excitatory neurotransmitter L-glutamic acid agonist. (RS)-AMPA does not interfere with binding sites for kainic acid or NMDA receptors[1][2].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR
In Vitro	(RS)-AMPA (10-3-10-4 M) causes depolarizations of cultured rat spinal and brainstem neurones. The depolarization by (RS)-AMPA is clearly dose-dependent, although there is a great variability of effects between individual neurones. Application of (RS)-AMPA at 10-5 M produces only small depolarizations (3-7 mV), whereas at 10-4 M, the amplitudes of the depolarizations ranged from 4 to 33 mV. (RS)-AMPA also causes an increase of the discharge rate of spontaneously firing neurones or sometimes evoked a short burst of action potentials in silent cells. (RS)-AMPA exerts its depolarizing effects by activating glutamate/quisqualate receptors without affecting NMDA receptors[1].
References	[1]. Hösli L, et al. Effects of the glutamate analogue AMPA and its interaction with antagonists on cultured rat spinal and brain stem neurones. Neurosci Lett. 1983 Mar 28;36(1):59-62. [2]. Sommer B, et al. Flip and flop: a cell-specific functional switch in glutamate-operated channels of the CNS. Science. 1990 Sep 28;249(4976):1580-5.

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