2-Iminobiotin hydrobromide

Modify Date: 2025-08-26 20:58:22

2-Iminobiotin hydrobromide structure	Common Name	2-Iminobiotin hydrobromide
	CAS Number	76985-52-9	Molecular Weight	324.24
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₀H₁₈BrN₃O₂S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of 2-Iminobiotin hydrobromide

2-Iminobiotin hydrobromide (Guanidinobiotin hydrobromide) is a biotin (vitamin H or B7) analog. 2-Iminobiotin hydrobromide is a reversible nitric oxide synthases inhibitor with Kis of 21.8 and 37.5 μM for murine iNOS and rat n-cNOS, respectively[1]. 2-Iminobiotin hydrobromide superimposes on hypothermia protects human neuronal cells from hypoxia-induced cell damage[2].

Name	2-Iminobiotin hydrobromide

Description	2-Iminobiotin hydrobromide (Guanidinobiotin hydrobromide) is a biotin (vitamin H or B7) analog. 2-Iminobiotin hydrobromide is a reversible nitric oxide synthases inhibitor with Kis of 21.8 and 37.5 μM for murine iNOS and rat n-cNOS, respectively[1]. 2-Iminobiotin hydrobromide superimposes on hypothermia protects human neuronal cells from hypoxia-induced cell damage[2].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> NO Synthase Research Areas >> Neurological Disease
Target	NO synthases[1]
In Vitro	Application of low concentrations of 2-Iminobiotin (2-IB; 10 ng/mL and 30 ng/mL) superimposed on hypothermia abrogates the hypoxia-induced lactate dehydrogenase (LDH) increase, resulting in LDH levels that were not different from the normoxia control[1].
References	[1]. Sup SJ, et al. 2-Iminobiotin is an inhibitor of nitric oxide synthases. Biochem Biophys Res Commun. 1994 Oct 28;204(2):962-8. [2]. Zitta K, et al. 2-Iminobiotin Superimposed on Hypothermia Protects Human Neuronal Cells from Hypoxia-Induced Cell Damage: An in Vitro Study. Front Pharmacol. 2018 Jan 11;8:971.

Molecular Formula	C₁₀H₁₈BrN₃O₂S
Molecular Weight	324.24
InChIKey	JKIJLCYOCQWMQL-UFLZEWODSA-N
SMILES	Br.NC1=NC2C(CSC2CCCCC(=O)O)N1

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2-Iminobiotin hydrobromide

Use of 2-Iminobiotin hydrobromide

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2-Iminobiotin hydrobromide Biological Activity

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