BAM-22P

Modify Date: 2024-01-02 15:38:55

BAM-22P structure	Common Name	BAM-22P
	CAS Number	76622-26-9	Molecular Weight	2839.22000
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₃₀H₁₈₄N₃₈O₃₁S₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of BAM-22P

BAM-22P, a highly potent opioid peptide, is a potent opioid agonist.

Name	Bam 22P
Synonym	More Synonyms

Description	BAM-22P, a highly potent opioid peptide, is a potent opioid agonist.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Opioid Receptor Signaling Pathways >> Neuronal Signaling >> Opioid Receptor Research Areas >> Neurological Disease Peptides
Target	Opioid receptor[1]
In Vivo	Bovine adrenal medulla docosapeptide (BAM-22P) is a potent opioid agonist, derived from the proenkephalin A gene, which is present in the adrenal medulla. Plasma levels of BAM-22P are determined by a sensitive radioimmunoassay, and the specificity of the assay is confirmed using high-performance liquid chromatography. Plasma BAM-22P levels s cholestatic rats are significantly higher than those in control rats. This increase in plasma BAM-22P levels is completely prevented by adrenalectomy. Adrenal steady-state levels of proenkephalin mRNA, as determined by Northern blot hybridization analyses, are also increased significantly in cholestatic rats. These increases in proenkephalin mRNA levels are not paralleled by changes in adrenal BAM-22P peptide levels, which are similar in cholestatic rats and their respective controls. Similar levels of proenkephalin mRNA expression are observed in innervated and denervated adrenal glands from cholestatic rats, suggesting that the increase in adrenal proenkephalin mRNA levels in acute cholestasis is not due to splanchnic nerve activation. Thus acute cholestasis in the rat is associated with adrenal secretion and accumulation in plasma of the highly potent opioid peptide BAM-22P and an augmentation of adrenal proenkephalin mRNA expression. The increase in plasma BAM-22P levels may contribute substantially to the increase in total circulating opioid activity documented in cholestatic rats. Adrenal gland levels of BAM-22P are similar in BDR and sham-resected rats (BDR, 1.10±0.39 ng/g; sham, 0.93±0.16 ng/g; NS). BAM-22P levels in ANIT-treated and oil-gavaged controls are also similar (ANIT, 2.88±0.29 ng/g; control, 2.75±0.30 ng/g; NS). However, adrenal BAM-22P levels are lower in BDR and sham-resected rats than in ANIT-treated and oil-gavaged controls (P<0.01). Acute cholestasis in the rat is associated with enhanced synthesis and secretion of the proen-kephalin-derived opioid peptide BAM-22P from the adrenal gland[1].
References	[1]. Swain MG, et al. Adrenal secretion of BAM-22P, a potent opioid peptide, is enhanced in rats with acute cholestasis. Am J Physiol. 1994 Feb;266(2 Pt 1):G201-5.

Molecular Formula	C₁₃₀H₁₈₄N₃₈O₃₁S₂
Molecular Weight	2839.22000
Exact Mass	2837.34000
PSA	1199.81000
LogP	7.71630
Storage condition	2-8℃

BAM-22P

GL Biochem (Shanghai) Ltd.
China
Product Name: BAM-22P
Price: $Inquiry/1g
Purity: 98.0%
Stocking Period: Inquiry
Contact: Jackie Yang

Zhejiang Hangyu API Co., Ltd
China
Product Name: BAM-22P
Price: $Inquiry/1kg
Purity: 99.0%
Stocking Period: 1 Day
Contact: Vinnie

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Price: $180/500ug

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