BAM(8-22)

Modify Date: 2025-09-12 11:46:22

BAM(8-22) Structure
BAM(8-22) structure
Common Name BAM(8-22)
CAS Number 412961-36-5 Molecular Weight 1971.20000
Density N/A Boiling Point N/A
Molecular Formula C91H127N25O23S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of BAM(8-22)


BAM(8-22), a proteolytically cleaved product of proenkephalin A, is a potent activator of Mas-related G-protein-coupled receptors (Mrgprs), MrgprC11 and hMrgprX1, and induces scratching in mice in an Mrgpr-dependent manner[1].

 Names

Name Val-Gly-Arg-Pro-Glu-Trp-Trp-Met-Asp-Tyr-Gln-Lys-Arg-Tyr-Gly
Synonym More Synonyms

 BAM(8-22) Biological Activity

Description BAM(8-22), a proteolytically cleaved product of proenkephalin A, is a potent activator of Mas-related G-protein-coupled receptors (Mrgprs), MrgprC11 and hMrgprX1, and induces scratching in mice in an Mrgpr-dependent manner[1].
Related Catalog
References

[1]. Parul Sikand, et al. BAM8-22 peptide produces itch and nociceptive sensations in humans independent of histamine release. J Neurosci. 2011 May 18;31(20):7563-7.

 Chemical & Physical Properties

Molecular Formula C91H127N25O23S
Molecular Weight 1971.20000
Exact Mass 1969.93000
PSA 826.78000
LogP 5.47110
InChIKey GOEYECACIBFJGZ-NPAGUKBMSA-N
SMILES CSCCC(NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(CCC(=O)O)NC(=O)C1CCCN1C(=O)C(CCCNC(=N)N)NC(=O)CNC(=O)C(N)C(C)C)C(=O)NC(CC(=O)O)C(=O)NC(Cc1ccc(O)cc1)C(=O)NC(CCC(N)=O)C(=O)NC(CCCCN)C(=O)NC(CCCNC(=N)N)C(=O)NC(Cc1ccc(O)cc1)C(=O)NCC(=O)O

 Synonyms

bam8-22
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