PTP1B-IN-4

Modify Date: 2025-08-27 09:43:43

PTP1B-IN-4 structure	Common Name	PTP1B-IN-4
	CAS Number	765317-72-4	Molecular Weight	741.448
	Density	1.8±0.1 g/cm3	Boiling Point	855.0±75.0 °C at 760 mmHg
	Molecular Formula	C₂₆H₁₉Br₂N₃O₇S₃	Melting Point	N/A
	MSDS	N/A	Flash Point	470.9±37.1 °C

Use of PTP1B-IN-4

PTP1B-IN-4 is a non-competitive allosteric inhibitor of the protein tyrosine phosphatase PTP1B, with an IC50 of 8 μM. PTP1B-IN-4 is potentail for the research of obesity and diabetes[1][2].

Name	3-(3,5-dibromo-4-hydroxybenzoyl)-2-ethyl-N-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]-1-benzofuran-6-sulfonamide
Synonym	More Synonyms

Description	PTP1B-IN-4 is a non-competitive allosteric inhibitor of the protein tyrosine phosphatase PTP1B, with an IC50 of 8 μM. PTP1B-IN-4 is potentail for the research of obesity and diabetes[1][2].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase Research Areas >> Metabolic Disease
Target	IC50: 8 μM (PTP1B)[1]
In Vitro	PTP1B-IN-4 (250 µM; 1 hour) stimulates insulin receptor (IR) phosphorylation in CHO cells overexpressing human IR[1]. PTP1B-IN-4 also induces phosphorylation of IRS-1 and Akt, proteins downstream of the insulin receptor[1]. Western Blot Analysis[1] Cell Line: CHO cells Concentration: 250 µM Incubation Time: 1 hour Result: Stimulated insulin receptor phosphorylation.
References	[1]. Wiesmann, C., et al. Allosteric inhibition of protein tyrosine phosphatase 1B. Nature Structural & Molecular Biology, 2004. 11(8), 730–737. [2]. Jin, T., et al. Selective binding modes and allosteric inhibitory effects of lupane triterpenes on protein tyrosine phosphatase 1B. Scientific Reports, 2016. 6(1).

Density	1.8±0.1 g/cm3
Boiling Point	855.0±75.0 °C at 760 mmHg
Molecular Formula	C₂₆H₁₉Br₂N₃O₇S₃
Molecular Weight	741.448
Flash Point	470.9±37.1 °C
Exact Mass	738.875183
PSA	200.67000
LogP	6.80
Vapour Pressure	0.0±3.3 mmHg at 25°C
Index of Refraction	1.727

3-(3,5-Dibromo-4-hydroxybenzoyl)-2-ethyl-N-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]-1-benzofuran-6-sulfonamide

1t4j

6-Benzofuransulfonamide, 3-(3,5-dibromo-4-hydroxybenzoyl)-2-ethyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]-

PTP1B Inhibitor

FRJ

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: PTP1B-IN-4
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: FRJ
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 3-(3,5-Dibromo-4-hydroxybenzoyl)-2-ethyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]-6-benzofuransulfonamide
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.