86109-60-6

86109-60-6 structure

Name: PTP1B-IN-22
Chemical Name: WYE-176244
CAS Number: 86109-60-6
Molecular Formula: C₁₆H₁₂N₂O₃S₂
Molecular Weight: 344.41
Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphatase
Create Date: 2023-01-11 20:30:19
Modify Date: 2024-04-11 21:55:17
PTP1B-IN-22, a ZINC02765569 derivative, is a potent protein tyrosine phosphatase 1B (PTP1B) inhibitor. PTP1B-IN-22 has PTP1B inhibition and glucose uptake in skeletal muscle L6 myotubes[1].

Name	WYE-176244
Synonyms	MFCD00396380 4-{[(1,3-Benzothiazol-2-ylsulfanyl)acetyl]amino}benzoic acid 4-(2-(BENZOTHIAZOL-2-YLSULFANYL)-ACETYLAMINO)-BENZOIC ACID Benzoic acid, 4-[[2-(2-benzothiazolylthio)acetyl]amino]-

Description	PTP1B-IN-22, a ZINC02765569 derivative, is a potent protein tyrosine phosphatase 1B (PTP1B) inhibitor. PTP1B-IN-22 has PTP1B inhibition and glucose uptake in skeletal muscle L6 myotubes[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase Research Areas >> Metabolic Disease
In Vitro	PTP1B-IN-22 (compound 3j; 骨骼肌 L6 肌管) 表现出 66.4% 的体外 PTP1B 抑制和 39.6% 的葡萄糖摄取增加[1]。
References	[1]. Prashant J, et, al. Molecular modeling and synthesis of ZINC02765569 derivatives as protein tyrosine phosphatase 1B inhibitors: lead optimization study. 2012;22: 1618-23.