765317-72-4

765317-72-4 structure

Name: PTP1B-IN-4
Chemical Name: 3-(3,5-dibromo-4-hydroxybenzoyl)-2-ethyl-N-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]-1-benzofuran-6-sulfonamide
CAS Number: 765317-72-4
Molecular Formula: C₂₆H₁₉Br₂N₃O₇S₃
Molecular Weight: 741.448
Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphatase
Create Date: 2017-01-10 22:38:36
Modify Date: 2024-01-07 21:00:44
PTP1B-IN-4 is a non-competitive allosteric inhibitor of the protein tyrosine phosphatase PTP1B, with an IC50 of 8 μM. PTP1B-IN-4 is potentail for the research of obesity and diabetes[1][2].

Name	3-(3,5-dibromo-4-hydroxybenzoyl)-2-ethyl-N-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]-1-benzofuran-6-sulfonamide
Synonyms	3-(3,5-Dibromo-4-hydroxybenzoyl)-2-ethyl-N-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]-1-benzofuran-6-sulfonamide 1t4j 6-Benzofuransulfonamide, 3-(3,5-dibromo-4-hydroxybenzoyl)-2-ethyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]- PTP1B Inhibitor FRJ

Description	PTP1B-IN-4 is a non-competitive allosteric inhibitor of the protein tyrosine phosphatase PTP1B, with an IC50 of 8 μM. PTP1B-IN-4 is potentail for the research of obesity and diabetes[1][2].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase Research Areas >> Metabolic Disease
Target	IC50: 8 μM (PTP1B)[1]
In Vitro	PTP1B-IN-4 (250 µM; 1 hour) stimulates insulin receptor (IR) phosphorylation in CHO cells overexpressing human IR[1]. PTP1B-IN-4 also induces phosphorylation of IRS-1 and Akt, proteins downstream of the insulin receptor[1]. Western Blot Analysis[1] Cell Line: CHO cells Concentration: 250 µM Incubation Time: 1 hour Result: Stimulated insulin receptor phosphorylation.
References	[1]. Wiesmann, C., et al. Allosteric inhibition of protein tyrosine phosphatase 1B. Nature Structural & Molecular Biology, 2004. 11(8), 730–737. [2]. Jin, T., et al. Selective binding modes and allosteric inhibitory effects of lupane triterpenes on protein tyrosine phosphatase 1B. Scientific Reports, 2016. 6(1).