Morachalcone A

Modify Date: 2025-08-25 17:11:14

Morachalcone A structure	Common Name	Morachalcone A
	CAS Number	76472-88-3	Molecular Weight	340.37
	Density	1.3±0.1 g/cm3	Boiling Point	605.0±55.0 °C at 760 mmHg
	Molecular Formula	C₂₀H₂₀O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	333.7±28.0 °C

Use of Morachalcone A

Morachalcone A is a naturally-occurring aromatase inhibitor (IC50=4.6 mM). Morachalcone A is also a plants metabolite with potential anti-inflammatory and anticancer activity. Morachalcone A inhibits Lipopolysaccharide (HY-D1056)-induced nitric oxide production[1][2][3].

Name	(2E)-1-[2,4-Dihydroxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(2,4-dih ydroxyphenyl)-2-propen-1-one
Synonym	More Synonyms

Description	Morachalcone A is a naturally-occurring aromatase inhibitor (IC50=4.6 mM). Morachalcone A is also a plants metabolite with potential anti-inflammatory and anticancer activity. Morachalcone A inhibits Lipopolysaccharide (HY-D1056)-induced nitric oxide production[1][2][3].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> NO Synthase Research Areas >> Inflammation/Immunology
References	[1]. Brandt D R, et al. The synthetic preparation of naturally-occurring aromatase inhibitors, morachalcone A, isogemichalcone B, and isogemichalcone C[J]. Tetrahedron, 2013, 69(47): 9994-10002. [2]. Kang Y J, et al. Inhibitory effects of morachalcone A on lipopolysaccharide-induced nitric oxide production in raw 264.7 cells[J]. 2009. [3]. Ferlinahayati, et al. Phenolic constituents from the wood of Morus australis with cytotoxic activity. Z Naturforsch C J Biosci. 2008 Jan-Feb;63(1-2):35-9.

Description

Related Catalog

Signaling Pathways >> Immunology/Inflammation >> NO Synthase

Research Areas >> Inflammation/Immunology

References

[1]. Brandt D R, et al. The synthetic preparation of naturally-occurring aromatase inhibitors, morachalcone A, isogemichalcone B, and isogemichalcone C[J]. Tetrahedron, 2013, 69(47): 9994-10002.

[2]. Kang Y J, et al. Inhibitory effects of morachalcone A on lipopolysaccharide-induced nitric oxide production in raw 264.7 cells[J]. 2009.

[3]. Ferlinahayati, et al. Phenolic constituents from the wood of Morus australis with cytotoxic activity. Z Naturforsch C J Biosci. 2008 Jan-Feb;63(1-2):35-9.

Density	1.3±0.1 g/cm3
Boiling Point	605.0±55.0 °C at 760 mmHg
Molecular Formula	C₂₀H₂₀O₅
Molecular Weight	340.37
Flash Point	333.7±28.0 °C
Exact Mass	340.131073
PSA	97.99000
LogP	5.24
Vapour Pressure	0.0±1.8 mmHg at 25°C
Index of Refraction	1.680

Hazard Codes	Xi

(2E)-3-[2',4'-b...

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~44%

Morachalcone A

CAS#:76472-88-3

Literature: Brandt, Drew R.; Pannone, Kristina M.; Romano, Joseph J.; Casillas, Eduard G. Tetrahedron, 2013 , vol. 69, # 47 p. 9994 - 10002

2,4-Dihydroxyac...

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Morachalcone A

CAS#:76472-88-3