76472-88-3

76472-88-3 structure

Name: Morachalcone A
Chemical Name: (2E)-1-[2,4-Dihydroxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(2,4-dih ydroxyphenyl)-2-propen-1-one
CAS Number: 76472-88-3
Molecular Formula: C₂₀H₂₀O₅
Molecular Weight: 340.37
Catalog: Natural product Chalcone
Create Date: 2017-04-04 18:38:16
Modify Date: 2024-01-02 16:02:23
Morachalcone A is a naturally-occurring aromatase inhibitor (IC50=4.6 mM). Morachalcone A is also a plants metabolite with potential anti-inflammatory and anticancer activity. Morachalcone A inhibits Lipopolysaccharide (HY-D1056)-induced nitric oxide production[1][2][3].

Name	(2E)-1-[2,4-Dihydroxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(2,4-dih ydroxyphenyl)-2-propen-1-one
Synonyms	2-Propen-1-one, 1-[2,4-dihydroxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(2,4-dihydroxyphenyl)-, (2E)- morachalchone A BENZALACETOPHENONE 2,4,2',4'-tetrahydroxy-3'-prenylchalcone MorachalconeA Morachalcone A 1,3-diphenylprop-1-en-3-one BENZYLIDENEACETOPHENONE 3-PHENYLACRYLOPHENONE 2-BENZALACETOPHENONE 1,3-di-phenyl-prop-2-en-1-one (2E)-1-[2,4-Dihydroxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(2,4-dihydroxyphenyl)-2-propen-1-one trans-1,3-diphenyl-2-propen-1-one PHENYL STYRYL KETONE 1,3-diphenyl-2-propen-1-one TRANS-CHALCONE

Description	Morachalcone A is a naturally-occurring aromatase inhibitor (IC50=4.6 mM). Morachalcone A is also a plants metabolite with potential anti-inflammatory and anticancer activity. Morachalcone A inhibits Lipopolysaccharide (HY-D1056)-induced nitric oxide production[1][2][3].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> NO Synthase Research Areas >> Inflammation/Immunology
References	[1]. Brandt D R, et al. The synthetic preparation of naturally-occurring aromatase inhibitors, morachalcone A, isogemichalcone B, and isogemichalcone C[J]. Tetrahedron, 2013, 69(47): 9994-10002. [2]. Kang Y J, et al. Inhibitory effects of morachalcone A on lipopolysaccharide-induced nitric oxide production in raw 264.7 cells[J]. 2009. [3]. Ferlinahayati, et al. Phenolic constituents from the wood of Morus australis with cytotoxic activity. Z Naturforsch C J Biosci. 2008 Jan-Feb;63(1-2):35-9.

Hazard Codes	Xi

850868-90-5

~44%

76472-88-3

Literature: Brandt, Drew R.; Pannone, Kristina M.; Romano, Joseph J.; Casillas, Eduard G. Tetrahedron, 2013 , vol. 69, # 47 p. 9994 - 10002