Formamide

Modify Date: 2024-01-02 20:12:04

Formamide Structure
Formamide structure
Common Name Formamide
CAS Number 75-12-7 Molecular Weight 45.041
Density 1.0±0.1 g/cm3 Boiling Point 210.5±9.0 °C at 760 mmHg
Molecular Formula CH3NO Melting Point 2-3 °C(lit.)
MSDS Chinese USA Flash Point 81.1±18.7 °C
Symbol GHS08
GHS08
Signal Word Danger

 Use of Formamide


Formamide is an amide derived from formic acid and has been used as solvent for many ionic compounds.

 Names

Name formamide
Synonym More Synonyms

 Formamide Biological Activity

Description Formamide is an amide derived from formic acid and has been used as solvent for many ionic compounds.
Related Catalog

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 210.5±9.0 °C at 760 mmHg
Melting Point 2-3 °C(lit.)
Molecular Formula CH3NO
Molecular Weight 45.041
Flash Point 81.1±18.7 °C
Exact Mass 45.021465
PSA 43.09000
LogP -1.51
Vapour density 1.55 (vs air)
Vapour Pressure 0.2±0.4 mmHg at 25°C
Index of Refraction 1.370
Water Solubility miscible

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
LQ0525000
CHEMICAL NAME :
Formamide
CAS REGISTRY NUMBER :
75-12-7
LAST UPDATED :
199712
DATA ITEMS CITED :
42
MOLECULAR FORMULA :
C-H3-N-O
MOLECULAR WEIGHT :
45.05
WISWESSER LINE NOTATION :
ZVH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5577 mg/kg
TOXIC EFFECTS :
Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - ataxia Kidney, Ureter, Bladder - incontinence
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>13500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>4 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2450 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
1500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
6 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
1250 mg/kg
TOXIC EFFECTS :
Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Amphibian - frog
DOSE/DURATION :
30 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
3150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
910 mg/kg/26W-I
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS Liver - liver function tests impaired Kidney, Ureter, Bladder - proteinuria
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1500 ppm/6H/2W-I
TOXIC EFFECTS :
Blood - changes in leukocyte (WBC) count Blood - changes in platelet count Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
2 gm/kg
SEX/DURATION :
female 7 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
7980 mg/kg
SEX/DURATION :
female 7-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Administration onto the skin
DOSE :
1200 mg/kg
SEX/DURATION :
female 10-11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
910 mg/kg
SEX/DURATION :
female 6-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

MUTATION DATA

TYPE OF TEST :
Cytogenetic analysis
TEST SYSTEM :
Non-mammalian species Cells - not otherwise specified
REFERENCE :
CAANAT Comptes Rendus de l'Association des Anatomistes. (Nancy, France) V.1-56, 1899-1972. For publisher information, see ANOBAU. Volume(issue)/page/year: 56,712,1972 *** REVIEWS *** ACGIH TLV-TWA 18 mg/m3 (10 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 10 ppm (15 mg/m3);Skin JAN 1993 OEL-BELGIUM:TWA 10 ppm (18 mg/m3);Skin JAN 1993 OEL-DENMARK:TWA 20 ppm (30 mg/m3) JAN 1993 OEL-FINLAND:TWA 20 ppm (37 mg/m3);STEL 30 ppm (55 mg/m3);Skin JAN 1993 OEL-FRANCE:TWA 20 ppm (30 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 20 ppm (30 mg/m3) JAN 1993 OEL-RUSSIA:STEL 3 mg/m3 JAN 1993 OEL-SWITZERLAND:TWA 20 ppm (37 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 20 ppm (30 mg/m3);STEL 30 ppm (45 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO FORMAMIDE-air:10H TWA 10 ppm (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84454 No. of Facilities: 227 (estimated) No. of Industries: 6 No. of Occupations: 14 No. of Employees: 3195 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84454 No. of Facilities: 42 (estimated) No. of Industries: 3 No. of Occupations: 5 No. of Employees: 2724 (estimated) No. of Female Employees: 556 (estimated)

 Safety Information

Symbol GHS08
GHS08
Signal Word Danger
Hazard Statements H351-H360D-H373
Precautionary Statements P201-P281-P308 + P313
Target Organs Blood
Personal Protective Equipment Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes T:Toxic
Risk Phrases R61
Safety Phrases S53-S45-S36/37/39-S26-S23
RIDADR NONH for all modes of transport
WGK Germany 2
RTECS LQ0525000
HS Code 2924199090

 Synthetic Route

~%

Formamide Structure

Formamide

CAS#:75-12-7

Literature: Maier, Guenther; Endres, Joerg European Journal of Organic Chemistry, 2000 , # 6 p. 1061 - 1063

 Precursor & DownStream

Precursor  1

DownStream  0

 Customs

HS Code 2924199090
Summary 2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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 Synonyms

Formic amide
potassium deuteroformate
methanimidic acid
formamidic acid
MFCD00007941
Formamide
AMINOFORMALDEHYDE
Hydroxyformaldimin
Formimidsaeure
formic-d acid,potassium salt
EINECS 200-842-0
Formamine
formimidic acid
Kalium-d-formiat
Potassium formate-d
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