K-777
Modify Date: 2025-09-12 22:58:31
K-777 structure
|
Common Name | K-777 | ||
|---|---|---|---|---|
| CAS Number | 749860-43-3 | Molecular Weight | 641.5 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C28H32F4IN5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of K-777K-777 is a potent and selective CCR4 antagonist that inhibits both CCL17 binding and CCL17-induced chemotaxis in Hut78 cells with IC50 of 57 and 8.9 nM respectively; induces CCR4 internalization, reduces cell surface CCR4. |
| Name | K-777 |
|---|
| Description | K-777 is a potent and selective CCR4 antagonist that inhibits both CCL17 binding and CCL17-induced chemotaxis in Hut78 cells with IC50 of 57 and 8.9 nM respectively; induces CCR4 internalization, reduces cell surface CCR4. |
|---|---|
| References | References 1. Sato T, et al. Pharmacology. 2013;91(5-6):305-13. 2. Solari R, et al. Eur J Pharmacol. 2015 Sep 15;763(Pt B):169-77. View Related Products by Target Chemokine Receptor (CCR and CXCR) |
| Molecular Formula | C28H32F4IN5 |
|---|---|
| Molecular Weight | 641.5 |
| InChIKey | JGMIJYAEFFHLTL-UHFFFAOYSA-N |
| SMILES | C[N+]1(C2CCN(c3ncc(-c4ccc(F)cc4F)c(NCc4ccc(F)cc4F)n3)CC2)CCCCC1 |