K-975

Modify Date: 2024-01-03 12:57:39

K-975 structure	Common Name	K-975
	CAS Number	2563855-03-6	Molecular Weight	287.74
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₆H₁₄ClNO₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of K-975

K-975 is a first-in-class TEAD inhibitor, directly inhibiting YAP/TAZ-TEAD protein-protein interaction and showing a potent anti-tumor effect in malignant pleural mesothelioma. K-975 was covalently bound to an internal cysteine residue located in the palmitate-binding pocket of TEAD. K-975 had a strong inhibitory effect against protein-protein interactions between YAP1/TAZ and TEAD in cell-free and cell-based assays.

Name	K-975

Description	K-975 is a first-in-class TEAD inhibitor, directly inhibiting YAP/TAZ-TEAD protein-protein interaction and showing a potent anti-tumor effect in malignant pleural mesothelioma. K-975 was covalently bound to an internal cysteine residue located in the palmitate-binding pocket of TEAD. K-975 had a strong inhibitory effect against protein-protein interactions between YAP1/TAZ and TEAD in cell-free and cell-based assays.

Description

Molecular Formula	C₁₆H₁₄ClNO₂
Molecular Weight	287.74
Storage condition	-20°C

DC Chemicals Limited
China
Product Name: K-975
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Cao

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K-975

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K-975 Biological Activity

Chemical & Physical Properties