2141978-86-9
2141978-86-9 structure
- Name: K 22
- Chemical Name: ZIKV inhibitor K22
- CAS Number: 2141978-86-9
- Molecular Formula: C27H25BrN2O3
- Molecular Weight: 505.412
- Create Date: 2020-01-20 10:45:56
- Modify Date: 2024-04-11 18:43:42
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ZIKV inhibitor K22 is a small molecule that exerts a potent antiviral activity against a broad range of coronaviruses by targeting membrane-bound viral RNA replication, effectively inhibits ZIKV with IC50 of 2.1 uM (48 h p.i); inhibits several members of the family Flaviviridae, blocks replication of ZIKV, yellow fever virus (YFV), Japanese encephalitis virus (JEV), West Nile virus (WNV), as well as to a certain extent, Usutu virus (USUV), Wesselsbron virus (WESSV), HCV and bovine viral diarrhea virus (BVDV) with IC50s <10 uM; act on early post-entry stages of coronavirus replication and to target membrane-bound viral RNA synthesis.
| Name | ZIKV inhibitor K22 |
|---|
| Description | ZIKV inhibitor K22 is a small molecule that exerts a potent antiviral activity against a broad range of coronaviruses by targeting membrane-bound viral RNA replication, effectively inhibits ZIKV with IC50 of 2.1 uM (48 h p.i); inhibits several members of the family Flaviviridae, blocks replication of ZIKV, yellow fever virus (YFV), Japanese encephalitis virus (JEV), West Nile virus (WNV), as well as to a certain extent, Usutu virus (USUV), Wesselsbron virus (WESSV), HCV and bovine viral diarrhea virus (BVDV) with IC50s <10 uM; act on early post-entry stages of coronavirus replication and to target membrane-bound viral RNA synthesis. |
|---|---|
| References | References 1. García-Nicolás O, et al. Antimicrob Agents Chemother. 2018 Sep 4. pii: AAC.01206-18. View Related Products by Target Filovirus |
| Molecular Formula | C27H25BrN2O3 |
|---|---|
| Molecular Weight | 505.412 |