K 22
Modify Date: 2025-11-27 11:49:20
K 22 structure
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Common Name | K 22 | ||
|---|---|---|---|---|
| CAS Number | 2141978-86-9 | Molecular Weight | 505.412 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C27H25BrN2O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of K 22ZIKV inhibitor K22 is a small molecule that exerts a potent antiviral activity against a broad range of coronaviruses by targeting membrane-bound viral RNA replication, effectively inhibits ZIKV with IC50 of 2.1 uM (48 h p.i); inhibits several members of the family Flaviviridae, blocks replication of ZIKV, yellow fever virus (YFV), Japanese encephalitis virus (JEV), West Nile virus (WNV), as well as to a certain extent, Usutu virus (USUV), Wesselsbron virus (WESSV), HCV and bovine viral diarrhea virus (BVDV) with IC50s <10 uM; act on early post-entry stages of coronavirus replication and to target membrane-bound viral RNA synthesis. |
| Name | ZIKV inhibitor K22 |
|---|
| Description | ZIKV inhibitor K22 is a small molecule that exerts a potent antiviral activity against a broad range of coronaviruses by targeting membrane-bound viral RNA replication, effectively inhibits ZIKV with IC50 of 2.1 uM (48 h p.i); inhibits several members of the family Flaviviridae, blocks replication of ZIKV, yellow fever virus (YFV), Japanese encephalitis virus (JEV), West Nile virus (WNV), as well as to a certain extent, Usutu virus (USUV), Wesselsbron virus (WESSV), HCV and bovine viral diarrhea virus (BVDV) with IC50s <10 uM; act on early post-entry stages of coronavirus replication and to target membrane-bound viral RNA synthesis. |
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| References | References 1. García-Nicolás O, et al. Antimicrob Agents Chemother. 2018 Sep 4. pii: AAC.01206-18. View Related Products by Target Filovirus |
| Molecular Formula | C27H25BrN2O3 |
|---|---|
| Molecular Weight | 505.412 |
| InChIKey | CMBUSPXASRNJHI-CLCOLTQESA-N |
| SMILES | O=C(NC(=Cc1ccccc1)C(=O)N1CCC(O)(c2ccc(Br)cc2)CC1)c1ccccc1 |