UBP 296

Modify Date: 2024-01-15 04:41:54

UBP 296 Structure
UBP 296 structure
 Common Name UBP 296
CAS Number 745055-86-1 Molecular Weight 333.30
Density 1.5±0.1 g/cm3 Boiling Point 603.0±65.0 °C at 760 mmHg
Molecular Formula C15H15N3O6 Melting Point N/A
MSDS N/A Flash Point 318.5±34.3 °C

 Use of UBP 296


UBP296 is a potent and selective antagonist of GLUK5-containing kainate receptor in the spinal cord. UBP296 reversibly blocks ATPA-induced depressions of synaptic transmission, and affects AMPA receptor-mediated synaptic transmission directly in rat hippocampal slices[1].

 Names

Name 2-[[3-(2-amino-2-carboxyethyl)-2,6-dioxo-1-pyrimidinyl]methyl]benzoic acid
Synonym More Synonyms

 UBP 296 Biological Activity

Description UBP296 is a potent and selective antagonist of GLUK5-containing kainate receptor in the spinal cord. UBP296 reversibly blocks ATPA-induced depressions of synaptic transmission, and affects AMPA receptor-mediated synaptic transmission directly in rat hippocampal slices[1].
Related Catalog
Target

IC50: 3.5 ± 1.5 μM (GLUK5), 4.0 ± 0.7 μM (GLUK5/GLUK6), 7.0 ± 5.1 μM (GLUK5/GLUK2)[1]

References

[1]. More JC, et al. Characterisation of UBP296: a novel, potent and selective kainate receptor antagonist. Neuropharmacology. 2004 Jul;47(1):46-64.

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 603.0±65.0 °C at 760 mmHg
Molecular Formula C15H15N3O6
Molecular Weight 333.30
Flash Point 318.5±34.3 °C
Exact Mass 333.096100
LogP 1.58
Vapour Pressure 0.0±1.8 mmHg at 25°C
Index of Refraction 1.659

 Synonyms

2-{[3-(2-Amino-2-carboxyethyl)-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl]methyl}benzoic acid
1(2H)-Pyrimidinepropanoic acid, α-amino-3-[(2-carboxyphenyl)methyl]-3,4-dihydro-2,4-dioxo-
2-[[3-(2-amino-2-carboxyethyl)-2,6-dioxo-1-pyrimidinyl]methyl]benzoic acid
2-{[3-(2-Amino-2-carboxyethyl)-2,6-dioxo-3,6-dihydro-1(2H)-pyrimidinyl]methyl}benzoic acid
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Chemsrc provides UBP 296(CAS#:745055-86-1) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of UBP 296 are included as well.>> amp version: UBP 296

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