Hippuryl-Phe-OH

Modify Date: 2025-08-25 18:28:52

Hippuryl-Phe-OH Structure
Hippuryl-Phe-OH structure
 Common Name Hippuryl-Phe-OH
CAS Number 744-59-2 Molecular Weight 326.346
Density 1.3±0.1 g/cm3 Boiling Point 673.3±55.0 °C at 760 mmHg
Molecular Formula C18H18N2O4 Melting Point 140-144ºC
MSDS Chinese USA Flash Point 361.0±31.5 °C

 Use of Hippuryl-Phe-OH


Hippuryl-L-phenylalanine is a substrate of carboxypeptidase. Carboxypeptidase is a protease enzyme that related with obesity, epilepsy and neurodegeneration. Hippuryl-L-phenylalanine can be used for the determination of carboxypeptidase activity[1][2].

 Names

Name n-benzoyl-gly-phe
Synonym More Synonyms

 Hippuryl-Phe-OH Biological Activity

Description Hippuryl-L-phenylalanine is a substrate of carboxypeptidase. Carboxypeptidase is a protease enzyme that related with obesity, epilepsy and neurodegeneration. Hippuryl-L-phenylalanine can be used for the determination of carboxypeptidase activity[1][2].
Related Catalog
References

[1]. Serafin WE, et al. Carboxypeptidase A in mouse mast cells. Identification, characterization, and use as a differentiation marker. J Immunol. 1987 Dec 1;139(11):3771-6.  

[2]. Sapio MR, Fricker LD. Carboxypeptidases in disease: insights from peptidomic studies. Proteomics Clin Appl. 2014 Jun;8(5-6):327-37.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 673.3±55.0 °C at 760 mmHg
Melting Point 140-144ºC
Molecular Formula C18H18N2O4
Molecular Weight 326.346
Flash Point 361.0±31.5 °C
Exact Mass 326.126648
PSA 95.50000
LogP 2.18
Vapour Pressure 0.0±2.2 mmHg at 25°C
Index of Refraction 1.600

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases S22-S24/25
RIDADR NONH for all modes of transport
HS Code 2924299090

 Synthetic Route

L-Phenylalanine structure

L-Phenylalanine

CAS#:63-91-2

p-nitrophenyl ester of benzoylaminoacetic acid structure

p-nitrophenyl e...

CAS#:3101-11-9

~75%

Hippuryl-Phe-OH Structure

Hippuryl-Phe-OH

CAS#:744-59-2

Literature: Litvinenko, L. M.; Kosmynin, V. V.; Kaida, L. N.; Savelova, V. A.; Verbovaya, I. P. Journal of Organic Chemistry USSR (English Translation), 1986 , vol. 22, # 4 p. 784 - 785 Zhurnal Organicheskoi Khimii, 1986 , vol. 22, # 4 p. 877 - 878
L-Phenylalanine structure

L-Phenylalanine

CAS#:63-91-2

N-[2-Oxo-2-(2-thioxo-3-thiazolidinyl)ethyl]benzamide structure

N-[2-Oxo-2-(2-t...

CAS#:80681-03-4

~69%

Hippuryl-Phe-OH Structure

Hippuryl-Phe-OH

CAS#:744-59-2

Literature: Chung-hsi, Li; Yuen-hwa, Yieh; Yao, Lin; Yong-jun, Lu; Ai-hsueh, Chi; Chi-yi, Hsing Tetrahedron Letters, 1981 , vol. 22, # 36 p. 3467 - 3470
Hippuric acid structure

Hippuric acid

CAS#:495-69-2

~%

Hippuryl-Phe-OH Structure

Hippuryl-Phe-OH

CAS#:744-59-2

Literature: Tetrahedron Letters, , vol. 22, # 36 p. 3467 - 3470
Benzoyl chloride structure

Benzoyl chloride

CAS#:98-88-4

~%

Hippuryl-Phe-OH Structure

Hippuryl-Phe-OH

CAS#:744-59-2

Literature: Tetrahedron Letters, , vol. 22, # 36 p. 3467 - 3470
3-benzoylthiazolidine-2-thion structure

3-benzoylthiazo...

CAS#:70326-37-3

~%

Hippuryl-Phe-OH Structure

Hippuryl-Phe-OH

CAS#:744-59-2

Literature: Tetrahedron Letters, , vol. 22, # 36 p. 3467 - 3470
PhCO-Gly-PheOMe structure

PhCO-Gly-PheOMe

CAS#:14281-55-1

~%

Hippuryl-Phe-OH Structure

Hippuryl-Phe-OH

CAS#:744-59-2

Literature: J. Gen. Chem. USSR (Engl. Transl.), , vol. 39, # 1 p. 92 - 96,81 - 83
2-Phenyloxazolin-5-one structure

2-Phenyloxazoli...

CAS#:1199-01-5

~%

Hippuryl-Phe-OH Structure

Hippuryl-Phe-OH

CAS#:744-59-2

Literature: J. Gen. Chem. USSR (Engl. Transl.), , vol. 39, # 1 p. 92 - 96,81 - 83
Methyl L-phenylalaninate hydrochloride structure

Methyl L-phenyl...

CAS#:7524-50-7

~%

Hippuryl-Phe-OH Structure

Hippuryl-Phe-OH

CAS#:744-59-2

Literature: J. Gen. Chem. USSR (Engl. Transl.), , vol. 39, # 1 p. 92 - 96,81 - 83

 Customs

HS Code 2924299090
Summary 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Articles9

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Structural and functional characterization of ochratoxinase, a novel mycotoxin-degrading enzyme.

Biochem. J. 462(3) , 441-52, (2014)

Ochratoxin, with ochratoxin A as the dominant form, is one of the five major mycotoxins most harmful to humans and animals. It is produced by Aspergillus and Penicillium species and occurs in a wide r...

Mast cell proteases.

Meth. Enzymol. 80 , 588, (1981)

Mechanisms for activation and inhibition of carboxypeptidase A catalyzed hydrolyses of peptides and esters.

Can. J. Biochem. 56 , 329, (1978)

3,3-Diphenylpropanoate (DPP) activates the carboxypeptidase A catalyzed hydrolysis of benzoylglycyl-L-phenylalanine (BzGly-L-Phe) (Ka = 2.1 x 10 (-3) M) and inhibits ester hydrolysis uncompetitively (...

 Synonyms

HIPPURYL-PHE-OH
BENZOYL-GLY-L-PHE
MFCD00037265
HIPPURYL-L-PHE
HIPP-L-PHE
Einecs 212-016-7
hippurylphenylalanine
L-Phenylalanine, N-benzoylglycyl-
hippuryl-L-phenylalanine
BENZOYL-GLY-PHE
HIPPURYL-PHE
BZ-GLY-PHE-OH
N-Benzoylglycyl-L-phenylalanine
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