Ranitidine S-Oxide

Modify Date: 2024-01-03 17:29:05

Ranitidine S-Oxide Structure
Ranitidine S-Oxide structure
Common Name Ranitidine S-Oxide
CAS Number 73851-70-4 Molecular Weight 330.40300
Density 1.265g/cm3 Boiling Point 527.5ºC at 760 mmHg
Molecular Formula C13H22N4O4S Melting Point N/A
MSDS Chinese USA Flash Point 272.8ºC
Symbol GHS07 GHS08
GHS07, GHS08
Signal Word Danger

 Use of Ranitidine S-Oxide


Ranitidine S-oxide is the metabolite of Ranitidine (HY-B0693). Ranitidine is a potent, selective and orally active histamine H2-receptor antagonist with an IC50 of 3.3 μM that inhibits gastric secretion[1][2].

 Names

Name Ranitidine S-Oxide
Synonym More Synonyms

 Ranitidine S-Oxide Biological Activity

Description Ranitidine S-oxide is the metabolite of Ranitidine (HY-B0693). Ranitidine is a potent, selective and orally active histamine H2-receptor antagonist with an IC50 of 3.3 μM that inhibits gastric secretion[1][2].
Related Catalog
References

[1]. Cross DM, et al. Kinetics of ranitidine metabolism in dog and rat isolated hepatocytes. Xenobiotica. 1995 Apr;25(4):367-75.

[2]. Leucuta A, et al. A pharmacokinetic interaction study between omeprazole and the H2-receptor antagonist ranitidine. Drug Metabol Drug Interact. 2004;20(4):273-81.

 Chemical & Physical Properties

Density 1.265g/cm3
Boiling Point 527.5ºC at 760 mmHg
Molecular Formula C13H22N4O4S
Molecular Weight 330.40300
Flash Point 272.8ºC
Exact Mass 330.13600
PSA 122.54000
LogP 2.64520
Index of Refraction 1.577
Storage condition Hygroscopic, -20°C Freezer, Under Inert Atmosphere

 Safety Information

Symbol GHS07 GHS08
GHS07, GHS08
Signal Word Danger
Hazard Statements H317-H334-H335
Precautionary Statements P261-P280-P342 + P311
Hazard Codes Xn
Risk Phrases 37-42/43
Safety Phrases 22-36/37
RIDADR NONH for all modes of transport

 Articles4

More Articles
Phenotypes of flavin-containing monooxygenase activity determined by ranitidine N-oxidation are positively correlated with genotypes of linked FM03 gene mutations in a Korean population.

Pharmacogenetics 10(1) , 67-78, (2000)

A non-invasive urine analysis method to determine the in-vivo flavin-containing mono-oxygenase (FMO) activity catalysing N-oxidation of ranitidine (RA) was developed and used to phenotype a Korean pop...

Qualitative and quantitative analysis of ranitidine and its metabolites by high-performance liquid chromatography-mass spectrometry.

J. Chromatogr. A. 323(1) , 143-52, (1985)

Reversed-phase high-performance liquid chromatography systems for the separation of ranitidine and its metabolites ranitidine-N-oxide, ranitidine-S-oxide, and desmethylranitidine have been developed f...

Sulphoxidation and sulphation capacity in patients with primary biliary cirrhosis.

J. Hepatol. 22(5) , 551-60, (1995)

We have previously reported an association of impaired S-oxidation with primary biliary cirrhosis. In order to confirm and further define this relationship, we retested S-oxidation capacity via three ...

 Synonyms

(E)-1-N'-[2-[[5-[(dimethylamino)methyl]furan-2-yl]methylsulfinyl]ethyl]-1-N-methyl-2-nitroethene-1,1-diamine
Ranitidine Impurity 3