Ranitidine S-Oxide

Names

[ Name ]:
Ranitidine S-Oxide

[Synonym ]:
(E)-1-N'-[2-[[5-[(dimethylamino)methyl]furan-2-yl]methylsulfinyl]ethyl]-1-N-methyl-2-nitroethene-1,1-diamine
Ranitidine Impurity 3

Biological Activity

[Description]:

Ranitidine S-oxide is the metabolite of Ranitidine (HY-B0693). Ranitidine is a potent, selective and orally active histamine H2-receptor antagonist with an IC50 of 3.3 μM that inhibits gastric secretion[1][2].

[Related Catalog]:

Research Areas >> Metabolic Disease

[References]

[1]. Cross DM, et al. Kinetics of ranitidine metabolism in dog and rat isolated hepatocytes. Xenobiotica. 1995 Apr;25(4):367-75.

[2]. Leucuta A, et al. A pharmacokinetic interaction study between omeprazole and the H2-receptor antagonist ranitidine. Drug Metabol Drug Interact. 2004;20(4):273-81.

Chemical & Physical Properties

[ Density]:
1.265g/cm3

[ Boiling Point ]:
527.5ºC at 760 mmHg

[ Molecular Formula ]:
C₁₃H₂₂N₄O₄S

[ Molecular Weight ]:
330.40300

[ Flash Point ]:
272.8ºC

[ Exact Mass ]:
330.13600

[ PSA ]:
122.54000

[ LogP ]:
2.64520

[ Index of Refraction ]:
1.577

[ Storage condition ]:
Hygroscopic, -20°C Freezer, Under Inert Atmosphere

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H317-H334-H335

[ Precautionary Statements ]:
P261-P280-P342 + P311

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
37-42/43

[ Safety Phrases ]:
22-36/37

[ RIDADR ]:
NONH for all modes of transport

Articles

Phenotypes of flavin-containing monooxygenase activity determined by ranitidine N-oxidation are positively correlated with genotypes of linked FM03 gene mutations in a Korean population.

Pharmacogenetics 10(1) , 67-78, (2000)

A non-invasive urine analysis method to determine the in-vivo flavin-containing mono-oxygenase (FMO) activity catalysing N-oxidation of ranitidine (RA) was developed and used to phenotype a Korean pop...

Qualitative and quantitative analysis of ranitidine and its metabolites by high-performance liquid chromatography-mass spectrometry.

J. Chromatogr. A. 323(1) , 143-52, (1985)

Reversed-phase high-performance liquid chromatography systems for the separation of ranitidine and its metabolites ranitidine-N-oxide, ranitidine-S-oxide, and desmethylranitidine have been developed f...

Sulphoxidation and sulphation capacity in patients with primary biliary cirrhosis.

J. Hepatol. 22(5) , 551-60, (1995)

We have previously reported an association of impaired S-oxidation with primary biliary cirrhosis. In order to confirm and further define this relationship, we retested S-oxidation capacity via three ...