cis-ABCD

Modify Date: 2024-01-05 11:27:10

cis-ABCD structure	Common Name	cis-ABCD
	CAS Number	73550-55-7	Molecular Weight	159.14000
	Density	1.568g/cm3	Boiling Point	288.1ºC at 760 mmHg
	Molecular Formula	C₆H₉NO₄	Melting Point	N/A
	MSDS	N/A	Flash Point	128ºC

Use of cis-ABCD

cis-ACBD is a potent and selective inhibitor of the high-affinity, Na+-dependent plasma membrane glutamate transporter. cis-ACBD is a glutamate reuptake inhibitor. cis-ACBD also acts as linear competitive inhibitor of the uptake of D-[3H]aspartate[1][2].

Name	cis-ACBD,cis-1-Aminocyclobutane-1,3-dicarboxylicacid
Synonym	More Synonyms

Description	cis-ACBD is a potent and selective inhibitor of the high-affinity, Na+-dependent plasma membrane glutamate transporter. cis-ACBD is a glutamate reuptake inhibitor. cis-ACBD also acts as linear competitive inhibitor of the uptake of D-[3H]aspartate[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
References	[1]. Ai J, et al. Presynaptic excitability as a potential target for the treatment of the traumatic cerebellum. Pharmacology. 2004 Aug;71(4):192-8. [2]. Griffiths R, et al. L-trans-pyrrolidine-2,4-dicarboxylate and cis-1-aminocyclobutane-1,3-dicarboxylate behave as transportable, competitive inhibitors of the high-affinity glutamate transporters. Biochem Pharmacol. 1994 Jan 20;47(2):267-74.

Description

Related Catalog

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

References

[1]. Ai J, et al. Presynaptic excitability as a potential target for the treatment of the traumatic cerebellum. Pharmacology. 2004 Aug;71(4):192-8.

[2]. Griffiths R, et al. L-trans-pyrrolidine-2,4-dicarboxylate and cis-1-aminocyclobutane-1,3-dicarboxylate behave as transportable, competitive inhibitors of the high-affinity glutamate transporters. Biochem Pharmacol. 1994 Jan 20;47(2):267-74.

Density	1.568g/cm3
Boiling Point	288.1ºC at 760 mmHg
Molecular Formula	C₆H₉NO₄
Molecular Weight	159.14000
Flash Point	128ºC
Exact Mass	159.05300
PSA	100.62000
Index of Refraction	1.587

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GU1685000

CHEMICAL NAME :: 1,3-Cyclobutanedicarboxylic acid, 1-amino-, cis-, hydrate

CAS REGISTRY NUMBER :: 73550-55-7

LAST UPDATED :: 199109

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C6-H9-N-O4.H2-O

MOLECULAR WEIGHT :: 177.18

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 33,2905,1990

CIS-1-AMINOCYCLOBUTANE-1,3-DICARBOXYLIC ACID

5-Methylfurmethiodide

TRANS-1-AMINOCYCLOBUTANE-1,3-DICARBOXYLIC ACID

CIS-2,4-METHANOGLUTAMIC ACID

CIS-ACBD

cis-1-Aminocyclobutan-1,3-dicarboxylic acid

1-amino-1,3-dicarboxycyclobutane

trans-2,4-methanoglutamic acid

1-AMINOCYCLOBUTANE-TRANS-1,3-DICARBOXYLIC ACID

2-methanoglutamic acid

cis-1-amino-1,3-cyclobutanedicarboxylicacid

TRANS-ACBD

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China
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cis-ABCD

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cis-ABCD Biological Activity

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CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

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