cis-ABCD

Modify Date: 2025-08-25 20:36:48

cis-ABCD structure	Common Name	cis-ABCD
	CAS Number	73550-55-7	Molecular Weight	159.14000
	Density	1.568g/cm3	Boiling Point	288.1ºC at 760 mmHg
	Molecular Formula	C₆H₉NO₄	Melting Point	N/A
	MSDS	N/A	Flash Point	128ºC

Use of cis-ABCD

cis-ACBD is a potent and selective inhibitor of the high-affinity, Na+-dependent plasma membrane glutamate transporter. cis-ACBD is a glutamate reuptake inhibitor. cis-ACBD also acts as linear competitive inhibitor of the uptake of D-[3H]aspartate[1][2].

Name	cis-ACBD,cis-1-Aminocyclobutane-1,3-dicarboxylicacid
Synonym	More Synonyms

Description	cis-ACBD is a potent and selective inhibitor of the high-affinity, Na+-dependent plasma membrane glutamate transporter. cis-ACBD is a glutamate reuptake inhibitor. cis-ACBD also acts as linear competitive inhibitor of the uptake of D-[3H]aspartate[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
References	[1]. Ai J, et al. Presynaptic excitability as a potential target for the treatment of the traumatic cerebellum. Pharmacology. 2004 Aug;71(4):192-8. [2]. Griffiths R, et al. L-trans-pyrrolidine-2,4-dicarboxylate and cis-1-aminocyclobutane-1,3-dicarboxylate behave as transportable, competitive inhibitors of the high-affinity glutamate transporters. Biochem Pharmacol. 1994 Jan 20;47(2):267-74.

Description

Related Catalog

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

References

[1]. Ai J, et al. Presynaptic excitability as a potential target for the treatment of the traumatic cerebellum. Pharmacology. 2004 Aug;71(4):192-8.

[2]. Griffiths R, et al. L-trans-pyrrolidine-2,4-dicarboxylate and cis-1-aminocyclobutane-1,3-dicarboxylate behave as transportable, competitive inhibitors of the high-affinity glutamate transporters. Biochem Pharmacol. 1994 Jan 20;47(2):267-74.

Density	1.568g/cm3
Boiling Point	288.1ºC at 760 mmHg
Molecular Formula	C₆H₉NO₄
Molecular Weight	159.14000
Flash Point	128ºC
Exact Mass	159.05300
PSA	100.62000
Index of Refraction	1.587

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GU1685000

CHEMICAL NAME :: 1,3-Cyclobutanedicarboxylic acid, 1-amino-, cis-, hydrate

CAS REGISTRY NUMBER :: 73550-55-7

LAST UPDATED :: 199109

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C6-H9-N-O4.H2-O

MOLECULAR WEIGHT :: 177.18

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 33,2905,1990

CIS-1-AMINOCYCLOBUTANE-1,3-DICARBOXYLIC ACID

5-Methylfurmethiodide

TRANS-1-AMINOCYCLOBUTANE-1,3-DICARBOXYLIC ACID

CIS-2,4-METHANOGLUTAMIC ACID

CIS-ACBD

cis-1-Aminocyclobutan-1,3-dicarboxylic acid

1-amino-1,3-dicarboxycyclobutane

trans-2,4-methanoglutamic acid

1-AMINOCYCLOBUTANE-TRANS-1,3-DICARBOXYLIC ACID

2-methanoglutamic acid

cis-1-amino-1,3-cyclobutanedicarboxylicacid

TRANS-ACBD

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cis-ABCD

Use of cis-ABCD

Names

cis-ABCD Biological Activity

Chemical & Physical Properties

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.