<Suppliers Price>

cis-ABCD

Names

[ CAS No. ]:
73550-55-7

[ Name ]:
cis-ABCD

[Synonym ]:
CIS-1-AMINOCYCLOBUTANE-1,3-DICARBOXYLIC ACID
5-Methylfurmethiodide
TRANS-1-AMINOCYCLOBUTANE-1,3-DICARBOXYLIC ACID
CIS-2,4-METHANOGLUTAMIC ACID
CIS-ACBD
cis-1-Aminocyclobutan-1,3-dicarboxylic acid
1-amino-1,3-dicarboxycyclobutane
trans-2,4-methanoglutamic acid
1-AMINOCYCLOBUTANE-TRANS-1,3-DICARBOXYLIC ACID
2-methanoglutamic acid
cis-1-amino-1,3-cyclobutanedicarboxylicacid
TRANS-ACBD

Biological Activity

[Description]:

cis-ACBD is a potent and selective inhibitor of the high-affinity, Na+-dependent plasma membrane glutamate transporter. cis-ACBD is a glutamate reuptake inhibitor. cis-ACBD also acts as linear competitive inhibitor of the uptake of D-[3H]aspartate[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Neurological Disease

[References]

[1]. Ai J, et al. Presynaptic excitability as a potential target for the treatment of the traumatic cerebellum. Pharmacology. 2004 Aug;71(4):192-8.

[2]. Griffiths R, et al. L-trans-pyrrolidine-2,4-dicarboxylate and cis-1-aminocyclobutane-1,3-dicarboxylate behave as transportable, competitive inhibitors of the high-affinity glutamate transporters. Biochem Pharmacol. 1994 Jan 20;47(2):267-74.

Chemical & Physical Properties

[ Density]:
1.568g/cm3

[ Boiling Point ]:
288.1ºC at 760 mmHg

[ Molecular Formula ]:
C6H9NO4

[ Molecular Weight ]:
159.14000

[ Flash Point ]:
128ºC

[ Exact Mass ]:
159.05300

[ PSA ]:
100.62000

[ Index of Refraction ]:
1.587

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GU1685000
CHEMICAL NAME :
1,3-Cyclobutanedicarboxylic acid, 1-amino-, cis-, hydrate
CAS REGISTRY NUMBER :
73550-55-7
LAST UPDATED :
199109
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C6-H9-N-O4.H2-O
MOLECULAR WEIGHT :
177.18

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>180 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 33,2905,1990

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.