cis-ABCD

Names

[ Name ]:
cis-ABCD

[Synonym ]:
CIS-1-AMINOCYCLOBUTANE-1,3-DICARBOXYLIC ACID
5-Methylfurmethiodide
TRANS-1-AMINOCYCLOBUTANE-1,3-DICARBOXYLIC ACID
CIS-2,4-METHANOGLUTAMIC ACID
CIS-ACBD
cis-1-Aminocyclobutan-1,3-dicarboxylic acid
1-amino-1,3-dicarboxycyclobutane
trans-2,4-methanoglutamic acid
1-AMINOCYCLOBUTANE-TRANS-1,3-DICARBOXYLIC ACID
2-methanoglutamic acid
cis-1-amino-1,3-cyclobutanedicarboxylicacid
TRANS-ACBD

Biological Activity

[Description]:

cis-ACBD is a potent and selective inhibitor of the high-affinity, Na+-dependent plasma membrane glutamate transporter. cis-ACBD is a glutamate reuptake inhibitor. cis-ACBD also acts as linear competitive inhibitor of the uptake of D-[3H]aspartate[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[References]

[1]. Ai J, et al. Presynaptic excitability as a potential target for the treatment of the traumatic cerebellum. Pharmacology. 2004 Aug;71(4):192-8.

[2]. Griffiths R, et al. L-trans-pyrrolidine-2,4-dicarboxylate and cis-1-aminocyclobutane-1,3-dicarboxylate behave as transportable, competitive inhibitors of the high-affinity glutamate transporters. Biochem Pharmacol. 1994 Jan 20;47(2):267-74.

Chemical & Physical Properties

[ Density]:
1.568g/cm3

[ Boiling Point ]:
288.1ºC at 760 mmHg

[ Molecular Formula ]:
C₆H₉NO₄

[ Molecular Weight ]:
159.14000

[ Flash Point ]:
128ºC

[ Exact Mass ]:
159.05300

[ PSA ]:
100.62000

[ Index of Refraction ]:
1.587

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GU1685000

CHEMICAL NAME :: 1,3-Cyclobutanedicarboxylic acid, 1-amino-, cis-, hydrate

CAS REGISTRY NUMBER :: 73550-55-7

LAST UPDATED :: 199109

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C6-H9-N-O4.H2-O

MOLECULAR WEIGHT :: 177.18

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 33,2905,1990