DL-PDMP

Modify Date: 2023-01-17 17:56:42

DL-PDMP Structure
DL-PDMP structure
Common Name DL-PDMP
CAS Number 73257-80-4 Molecular Weight 427.020
Density N/A Boiling Point 555.1ºC at 760 mmHg
Molecular Formula C23H39ClN2O3 Melting Point N/A
MSDS N/A Flash Point 289.5ºC

 Use of DL-PDMP


PDMP hydrochloride is a glucosylceramide synthase (GCS) inhibitor. PDMP hydrochloride induces apoptosis in K562/A02 cells. PDMP hydrochloride can be used in cancer (such as leukemia) research[1][2].

 Names

Name d,l-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol hcl
Synonym More Synonyms

 DL-PDMP Biological Activity

Description PDMP hydrochloride is a glucosylceramide synthase (GCS) inhibitor. PDMP hydrochloride induces apoptosis in K562/A02 cells. PDMP hydrochloride can be used in cancer (such as leukemia) research[1][2].
Related Catalog
References

[1]. Casson L, et al. Inhibition of ceramide metabolism sensitizes human leukemia cells to inhibition of BCL2-like proteins. PLoS One. 2013;8(1):e54525.  

[2]. Yin L, et al. Effect of PDMP, a glucosylceramide synthase inhibitor, on reversion of daunorubicin resistance in human leukemia cell line K562/A02. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2010 Feb;18(1):79-84.  

 Chemical & Physical Properties

Boiling Point 555.1ºC at 760 mmHg
Molecular Formula C23H39ClN2O3
Molecular Weight 427.020
Flash Point 289.5ºC
Exact Mass 426.264923
PSA 61.80000
LogP 4.80850

 Safety Information

WGK Germany 3

 Synonyms

(±)-threo-1-Phenyl-2-decanoylamino-3-morpholino-1-propanol hydrochloride
Decanamide, N-(2-hydroxy-1-(4-morpholinylmethyl)-2-phenylethyl)-, hydrochloride
(+/-)-threo-pdmp hydrochloride
rv 538
(+/-)-pdmp hydrochloride
(+/-)-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol hydrochloride
Decanamide, N-[2-hydroxy-1-(4-morpholinylmethyl)-2-phenylethyl]-, hydrochloride (1:1)
d,l-threo-pdmp hcl
N-[1-Hydroxy-3-(4-morpholinyl)-1-phenyl-2-propanyl]decanamide hydrochloride (1:1)
dl-pdmp
1-phenyl-2-decanoylamino-3-morpholino-1-propanol,hcl
dl-threo-pdmp,hydrochloride
N-(2-Hydroxy-1-(4-morpholinylmethyl)-2-phenylethyl)decanamide hydrochloride
(+/-)-pdmp hcl
PDMP hydrochloride
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