71183-66-9

71183-66-9 structure

Name: DL-threo-2-methylisocitrate
Chemical Name: DL-threo-2-methylisocitrate
CAS Number: 71183-66-9
Molecular Formula: C₁₄H₂₀O₁₄
Molecular Weight: 412.30
Catalog: Research Areas Infection
Create Date: 2018-12-15 11:26:20
Modify Date: 2024-01-10 19:00:55
DL-threo-2-methylisocitrate is a substrate of isocitrate lyase 1(ICL1).IC50 value:Target: The Km of purified recombinant ICL1 for threo-D(s)L(s)-isocitrate (ICA) was determined to be 188 μM using Michaelis-Menten non-linear least squares fit, with a kcat of 5.24 s-1. The Km for DL-threo-2-methylisocitrate (MICA) was approximately fourfold higher at 718 μM with a kcat of 1.25 s-1.

Name	DL-threo-2-methylisocitrate

Description	DL-threo-2-methylisocitrate is a substrate of isocitrate lyase 1(ICL1).IC50 value:Target: The Km of purified recombinant ICL1 for threo-D(s)L(s)-isocitrate (ICA) was determined to be 188 μM using Michaelis-Menten non-linear least squares fit, with a kcat of 5.24 s-1. The Km for DL-threo-2-methylisocitrate (MICA) was approximately fourfold higher at 718 μM with a kcat of 1.25 s-1.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Infection
References	[1]. Gould TA, et al. Dual role of isocitrate lyase 1 in the glyoxylate and methylcitrate cycles in Mycobacterium tuberculosis. Mol Microbiol. 2006 Aug;61(4):940-7.