73257-80-4

73257-80-4 structure

Name: DL-PDMP
Chemical Name: d,l-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol hcl
CAS Number: 73257-80-4
Molecular Formula: C₂₃H₃₉ClN₂O₃
Molecular Weight: 427.020
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2018-08-21 11:18:35
Modify Date: 2023-01-17 17:56:42
PDMP hydrochloride is a glucosylceramide synthase (GCS) inhibitor. PDMP hydrochloride induces apoptosis in K562/A02 cells. PDMP hydrochloride can be used in cancer (such as leukemia) research[1][2].

Name	d,l-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol hcl
Synonyms	(±)-threo-1-Phenyl-2-decanoylamino-3-morpholino-1-propanol hydrochloride Decanamide, N-(2-hydroxy-1-(4-morpholinylmethyl)-2-phenylethyl)-, hydrochloride (+/-)-threo-pdmp hydrochloride rv 538 (+/-)-pdmp hydrochloride (+/-)-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol hydrochloride Decanamide, N-[2-hydroxy-1-(4-morpholinylmethyl)-2-phenylethyl]-, hydrochloride (1:1) d,l-threo-pdmp hcl N-[1-Hydroxy-3-(4-morpholinyl)-1-phenyl-2-propanyl]decanamide hydrochloride (1:1) dl-pdmp 1-phenyl-2-decanoylamino-3-morpholino-1-propanol,hcl dl-threo-pdmp,hydrochloride N-(2-Hydroxy-1-(4-morpholinylmethyl)-2-phenylethyl)decanamide hydrochloride (+/-)-pdmp hcl PDMP hydrochloride

Description	PDMP hydrochloride is a glucosylceramide synthase (GCS) inhibitor. PDMP hydrochloride induces apoptosis in K562/A02 cells. PDMP hydrochloride can be used in cancer (such as leukemia) research[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
References	[1]. Casson L, et al. Inhibition of ceramide metabolism sensitizes human leukemia cells to inhibition of BCL2-like proteins. PLoS One. 2013;8(1):e54525. [2]. Yin L, et al. Effect of PDMP, a glucosylceramide synthase inhibitor, on reversion of daunorubicin resistance in human leukemia cell line K562/A02. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2010 Feb;18(1):79-84.

WGK Germany	3