NSC 15520
Modify Date: 2024-01-10 21:26:27
NSC 15520 structure
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Common Name | NSC 15520 | ||
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| CAS Number | 730960-98-2 | Molecular Weight | N/A | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | N/A | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of NSC 15520NSC15520 is a small molecular inhibitor of Replication Protein A (RPA). NSC15520 specifically recognizes the RPA N-terminal DNA binding domain (DBD), and blocks the interaction of RPA with p53 or RAD9. NSC15520 also inhibtis helix destabilization of a duplex DNA (dsDNA) oligonucleotide, involves in DNA replication, DNA repair, DNA recombination, and DNA damage response signaling[1]. |
| Name | NSC 15520 |
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| Description | NSC15520 is a small molecular inhibitor of Replication Protein A (RPA). NSC15520 specifically recognizes the RPA N-terminal DNA binding domain (DBD), and blocks the interaction of RPA with p53 or RAD9. NSC15520 also inhibtis helix destabilization of a duplex DNA (dsDNA) oligonucleotide, involves in DNA replication, DNA repair, DNA recombination, and DNA damage response signaling[1]. |
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| Related Catalog | |
| In Vitro | NSC15520 (10- 0.5 -10-3.5 M) 抑制 RPA 与 GST-p53 肽的相互作用，IC50 为 10 μM[1]。 Nsc15520 (0-400 μM; 5 min) 抑制螺旋不稳定活性[1]。 Nsc15520 (0-400 μM; 5 min) 抑制 RPA 结合 dsDNA 30-mer[1]。 |
| References |
| No Any Chemical & Physical Properties |