730960-98-2

730960-98-2 structure

Name: NSC 15520
Chemical Name: NSC 15520
CAS Number: 730960-98-2
Molecular Formula:
Molecular Weight:
Catalog: Research Areas Cancer
Create Date: 2021-09-10 19:19:31
Modify Date: 2024-01-10 21:26:27
NSC15520 is a small molecular inhibitor of Replication Protein A (RPA). NSC15520 specifically recognizes the RPA N-terminal DNA binding domain (DBD), and blocks the interaction of RPA with p53 or RAD9. NSC15520 also inhibtis helix destabilization of a duplex DNA (dsDNA) oligonucleotide, involves in DNA replication, DNA repair, DNA recombination, and DNA damage response signaling[1].

Name	NSC 15520

Description	NSC15520 is a small molecular inhibitor of Replication Protein A (RPA). NSC15520 specifically recognizes the RPA N-terminal DNA binding domain (DBD), and blocks the interaction of RPA with p53 or RAD9. NSC15520 also inhibtis helix destabilization of a duplex DNA (dsDNA) oligonucleotide, involves in DNA replication, DNA repair, DNA recombination, and DNA damage response signaling[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
In Vitro	NSC15520 (10- 0.5 -10-3.5 M) 抑制 RPA 与 GST-p53 肽的相互作用，IC50 为 10 μM[1]。 Nsc15520 (0-400 μM; 5 min) 抑制螺旋不稳定活性[1]。 Nsc15520 (0-400 μM; 5 min) 抑制 RPA 结合 dsDNA 30-mer[1]。
References	[1]. Glanzer JG, et al. Small molecule inhibitor of the RPA70 N-terminal protein interaction domain discovered using in silico and in vitro methods. Bioorg Med Chem. 2011 Apr 15;19(8):2589-95.

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