NSC 15520

Names

[ Name ]:
NSC 15520

Biological Activity

[Description]:

NSC15520 is a small molecular inhibitor of Replication Protein A (RPA). NSC15520 specifically recognizes the RPA N-terminal DNA binding domain (DBD), and blocks the interaction of RPA with p53 or RAD9. NSC15520 also inhibtis helix destabilization of a duplex DNA (dsDNA) oligonucleotide, involves in DNA replication, DNA repair, DNA recombination, and DNA damage response signaling[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[In Vitro]

NSC15520 (10- 0.5 -10-3.5 M) 抑制 RPA 与 GST-p53 肽的相互作用，IC50 为 10 μM[1]。 Nsc15520 (0-400 μM; 5 min) 抑制螺旋不稳定活性[1]。 Nsc15520 (0-400 μM; 5 min) 抑制 RPA 结合 dsDNA 30-mer[1]。

[References]

[1]. Glanzer JG, et al. Small molecule inhibitor of the RPA70 N-terminal protein interaction domain discovered using in silico and in vitro methods. Bioorg Med Chem. 2011 Apr 15;19(8):2589-95.

Chemical & Physical Properties

No Any Chemical & Physical Properties

Related Compounds

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