A-381393
Modify Date: 2024-01-07 22:32:06
A-381393 structure
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Common Name | A-381393 | ||
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| CAS Number | 726174-00-1 | Molecular Weight | 320.43 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H24N4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of A-381393A-381393 is a potent, selective, brain penetrate dopamine D4 receptor antagonist, with Kis of 1.5, 1.9 and 1.6 nM for human dopamine D4.4, D4.2, and D4.7 receptor, respectively, >2700-fold selectivity over D1, D2, D3 and D5 dopamine receptors. A-381393 shows moderate affinity for 5-HT2A (Ki, 370 nM)[1]. |
| Name | A-381393 |
|---|
| Description | A-381393 is a potent, selective, brain penetrate dopamine D4 receptor antagonist, with Kis of 1.5, 1.9 and 1.6 nM for human dopamine D4.4, D4.2, and D4.7 receptor, respectively, >2700-fold selectivity over D1, D2, D3 and D5 dopamine receptors. A-381393 shows moderate affinity for 5-HT2A (Ki, 370 nM)[1]. |
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| Related Catalog | |
| Target |
Ki: 1.5 nM (D4.4 receptor), 1.9 nM (D4.2 receptor), 1.6 nM (D4.7 receptor)[1] |
| In Vitro | A-381393 exhibits weak affinity at 5-HT1A, Sigma 2, Adenoceptor α1A, Adenoceptor α2C, Histamine H1, with Kis of 1365, 8600, 2044, 1912 and 2962 nM, respectively[1]. |
| References |
| Molecular Formula | C20H24N4 |
|---|---|
| Molecular Weight | 320.43 |
| Storage condition | 2-8℃ |