ZJ 43

Modify Date: 2024-01-02 09:53:37

ZJ 43 structure	Common Name	ZJ 43
	CAS Number	723331-20-2	Molecular Weight	304.30
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₂H₂₀N₂O₇	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of ZJ 43

ZJ43 is a potent NAAG peptidase inhibitor, with an IC50 of 2.4 nM and a Ki of 0.8 nM. ZJ43 sufficiently activates group II mGluR and reduces some of the behavioral effects of PCP. ZJ43 shows an analgesic effect in neuropathic and inflammatory and pain models[1].

Name	(2S)-2-[[(1S)-1-carboxy-3-methylbutyl]carbamoylamino]pentanedioic acid
Synonym	More Synonyms

Description	ZJ43 is a potent NAAG peptidase inhibitor, with an IC50 of 2.4 nM and a Ki of 0.8 nM. ZJ43 sufficiently activates group II mGluR and reduces some of the behavioral effects of PCP. ZJ43 shows an analgesic effect in neuropathic and inflammatory and pain models[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Aminopeptidase Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> mGluR Research Areas >> Neurological Disease
Target	IC50: 2.4 nM (NAAG)[1]
References	[1]. Olszewski RT, et al. NAAG peptidase inhibition reduces locomotor activity and some stereotypes in the PCP model of schizophrenia via group II mGluR. J Neurochem. 2004 May;89(4):876-85. [2]. Yamamoto T, et al. Antinociceptive effects of N-acetylaspartylglutamate (NAAG) peptidase inhibitors ZJ-11, ZJ-17 and ZJ-43 in the rat formalin test and in the rat neuropathic pain model. Eur J Neurosci. 2004 Jul;20(2):483-94.

Molecular Formula	C₁₂H₂₀N₂O₇
Molecular Weight	304.30
Exact Mass	304.12700
PSA	153.03000
LogP	0.88470

zj 43

DC Chemicals Limited
China
Product Name: ZJ43
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: N-[[[(1S)-1-CARBOXY-3-METHYLBUTYL]AMINO]CARBONYL]-L-GLUTAMIC ACID
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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