2287258-85-7
2287258-85-7 structure
- Name: HL-43
- Chemical Name: HL-43
- CAS Number: 2287258-85-7
- Molecular Formula: C26H23FN4O4
- Molecular Weight: 474.492
- Create Date: 2022-07-01 12:13:10
- Modify Date: 2025-08-25 12:53:43
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HL-43 (EP4 antagonist HL-43) is a selective prostaglandin E receptor 4 (EP4) antagonist, promotes chondrocyte differentiation/cartilage regeneration and anabolism with low toxicity;HL-43 exhibits the highest potency in inducing Col2a1 expression and reducing Mmp3 expression in presence of IL-1β.HL-43 downregulats Mmp3/13 expression in a dose-dependent manner.HL-43 induces anabolic factors (ACAN and SOX9), and suppresses catabolic factor (MMP13), and hypertrophic marker (COLX), inhibits the STAT3 catabolic pathway;.HL-43 promotes chondrocyte differentiation and ECM generation, and inhibits matrix degradation in both human and mouse articular cartilage explants.HL-43 enhances cartilage repair and regeneration in different artilage defect (CD) animal models.
| Name | HL-43 |
|---|
| Description | HL-43 (EP4 antagonist HL-43) is a selective prostaglandin E receptor 4 (EP4) antagonist, promotes chondrocyte differentiation/cartilage regeneration and anabolism with low toxicity;HL-43 exhibits the highest potency in inducing Col2a1 expression and reducing Mmp3 expression in presence of IL-1β.HL-43 downregulats Mmp3/13 expression in a dose-dependent manner.HL-43 induces anabolic factors (ACAN and SOX9), and suppresses catabolic factor (MMP13), and hypertrophic marker (COLX), inhibits the STAT3 catabolic pathway;.HL-43 promotes chondrocyte differentiation and ECM generation, and inhibits matrix degradation in both human and mouse articular cartilage explants.HL-43 enhances cartilage repair and regeneration in different artilage defect (CD) animal models. |
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| References | 1. Yunyun Jin, et al. Cell Discov. 2022 Mar 8;8(1):24. |
| Molecular Formula | C26H23FN4O4 |
|---|---|
| Molecular Weight | 474.492 |