723331-20-2

723331-20-2 structure

Name: ZJ 43
Chemical Name: (2S)-2-[[(1S)-1-carboxy-3-methylbutyl]carbamoylamino]pentanedioic acid
CAS Number: 723331-20-2
Molecular Formula: C₁₂H₂₀N₂O₇
Molecular Weight: 304.30
Catalog: Signaling Pathways GPCR/G Protein mGluR
Create Date: 2017-11-22 00:21:22
Modify Date: 2024-01-02 09:53:37
ZJ43 is a potent NAAG peptidase inhibitor, with an IC50 of 2.4 nM and a Ki of 0.8 nM. ZJ43 sufficiently activates group II mGluR and reduces some of the behavioral effects of PCP. ZJ43 shows an analgesic effect in neuropathic and inflammatory and pain models[1].

Name	(2S)-2-[[(1S)-1-carboxy-3-methylbutyl]carbamoylamino]pentanedioic acid
Synonyms	zj 43

Description	ZJ43 is a potent NAAG peptidase inhibitor, with an IC50 of 2.4 nM and a Ki of 0.8 nM. ZJ43 sufficiently activates group II mGluR and reduces some of the behavioral effects of PCP. ZJ43 shows an analgesic effect in neuropathic and inflammatory and pain models[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Aminopeptidase Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> mGluR Research Areas >> Neurological Disease
Target	IC50: 2.4 nM (NAAG)[1]
References	[1]. Olszewski RT, et al. NAAG peptidase inhibition reduces locomotor activity and some stereotypes in the PCP model of schizophrenia via group II mGluR. J Neurochem. 2004 May;89(4):876-85. [2]. Yamamoto T, et al. Antinociceptive effects of N-acetylaspartylglutamate (NAAG) peptidase inhibitors ZJ-11, ZJ-17 and ZJ-43 in the rat formalin test and in the rat neuropathic pain model. Eur J Neurosci. 2004 Jul;20(2):483-94.