Lincomycin Hydrochloride Monohydrate

Modify Date: 2024-01-03 09:27:09

Lincomycin Hydrochloride Monohydrate Structure
Lincomycin Hydrochloride Monohydrate structure
Common Name Lincomycin Hydrochloride Monohydrate
CAS Number 7179-49-9 Molecular Weight 461.014
Density N/A Boiling Point 646.8ºC at 760 mmHg
Molecular Formula C18H37ClN2O7S Melting Point 154 °C
MSDS USA Flash Point 345ºC

 Use of Lincomycin Hydrochloride Monohydrate


Lincomycin hydrochloride monohydrate is a narrow-spectrum antibiotic, has similar effects to erythromycin, which has a good effect on gram-positive coccus, mainly used to inhibit the synthesis of bacterial cell protein.

 Names

Name Lincocin Hydrochloride Monohydrate
Synonym More Synonyms

 Lincomycin Hydrochloride Monohydrate Biological Activity

Description Lincomycin hydrochloride monohydrate is a narrow-spectrum antibiotic, has similar effects to erythromycin, which has a good effect on gram-positive coccus, mainly used to inhibit the synthesis of bacterial cell protein.
Related Catalog

 Chemical & Physical Properties

Boiling Point 646.8ºC at 760 mmHg
Melting Point 154 °C
Molecular Formula C18H37ClN2O7S
Molecular Weight 461.014
Flash Point 345ºC
Exact Mass 460.200989
PSA 157.02000
LogP 0.20950
Storage condition 2-8°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RH6315500
CHEMICAL NAME :
D-erythro-D-Galacto-octopyranoside, methyl 6,8-dideoxy-6-(1-methyl-4-propyl- 2-pyrrolidinecarboxamido)-1-thio-, monohydrochloride, hemihydrate
CAS REGISTRY NUMBER :
7179-49-9
LAST UPDATED :
199512
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C18-H34-N2-O6-S.Cl-H.H2-O
MOLECULAR WEIGHT :
461.08
WISWESSER LINE NOTATION :
T6OTJ BS1 CQ DQ EQ FYYQ1&MV- BT5NTJ A1 D3 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
192 mg/kg/8D-I
TOXIC EFFECTS :
Blood - normocytic anemia
REFERENCE :
PGMJAO Postgraduate Medical Journal. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1925- Volume(issue)/page/year: 59,796,1983
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>4 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
UPJOH* "Compounds Available for Fundamental Research, Volume II-6, Antibiotics, A Program of Upjohn Company Research Laboratory." (Kalamazoo, MI 49001) Volume(issue)/page/year: 2(6),-,1971
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
9778 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969 Volume(issue)/page/year: -,65,1969
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
342 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,891,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
UPJOH* "Compounds Available for Fundamental Research, Volume II-6, Antibiotics, A Program of Upjohn Company Research Laboratory." (Kalamazoo, MI 49001) Volume(issue)/page/year: 2(6),-,1971
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
214 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,891,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1523 No. of Facilities: 56 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 4111 (estimated) No. of Female Employees: 3872 (estimated)

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi: Irritant;
Risk Phrases R36/37/38
Safety Phrases 26
RIDADR NONH for all modes of transport
RTECS RH6315500

 Articles31

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This paper describes an extension and performance characterization of a quantitative confirmatory multi-residue liquid chromatography-tandem mass spectrometric method for residues of macrolide and lin...

Gene expression of ribosomal protein mRNA inChironomus riparius: Effects of endocrine disruptor chemicals and antibiotics

Comp. Biochem. Physiol. C. Toxicol. Pharmacol. 156(2) , 113-20, (2012)

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Ecotoxicol. Environ. Saf. 108 , 52-7, (2014)

Pharmaceutically active compounds (PACs) are continuously dispersed into the environment due to human and veterinary use, giving rise to their potential accumulation in edible plants. In this study, E...

 Synonyms

(2S-trans)-Methyl 6,8-Dideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio-D-erythro-a-D-galactooctopyranoside Monohydrochloride Monohydrate
Methyl (5R)-5-[(1R,2R)-2-hydroxy-1-{[(4R)-1-methyl-4-propyl-L-prolyl]amino}propyl]-1-thio-β-L-arabinopyranoside hydrochloride hydrate
Lincomycin hydrochloride monohydrate
EINECS 212-726-7
Frademicina
MFCD00167245
Waynecomycin
mycivin
Cillimycin
Methyl 6,8-dideoxy-6-{[(4R)-1-methyl-4-propyl-L-prolyl]amino}-1-thio-D-erythro-α-D-galacto-octopyranoside hydrochloride hydrate
D-erythro-α-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-, hydrochloride, hydrate (1:1:1)
Lincomix
Lincomycin, hydrochloride hydrate
Lincomycin (hydrochloride hydrate)
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