5-Hydroxydecanoate sodium
5-Hydroxydecanoate sodium structure
|
Common Name | 5-Hydroxydecanoate sodium | ||
|---|---|---|---|---|
| CAS Number | 71186-53-3 | Molecular Weight | 210.24600 | |
| Density | N/A | Boiling Point | 320.8ºC at 760 mmHg | |
| Molecular Formula | C10H19NaO3 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 162ºC | |
Use of 5-Hydroxydecanoate sodium5-Hydroxydecanoate sodium is a selective ATP-sensitive K+ (KATP) channel blocker (IC50 of ~30 μM). 5-Hydroxydecanoate sodium is a substrate for mitochondrial outer membrane acyl-CoA synthetase and has antioxidant activity[1][2]. |
| Name | 5-hydroxydecanoic acid sodium salt |
|---|---|
| Synonym | More Synonyms |
| Description | 5-Hydroxydecanoate sodium is a selective ATP-sensitive K+ (KATP) channel blocker (IC50 of ~30 μM). 5-Hydroxydecanoate sodium is a substrate for mitochondrial outer membrane acyl-CoA synthetase and has antioxidant activity[1][2]. |
|---|---|
| Related Catalog | |
| Target |
IC50: ~30 μM (KATP) |
| In Vitro | 5-Hydroxydecanoate (5-HD) treatment abolishs the beneficial effects of penehyclidine hydrochloride (PHC) preconditioning in anoxia/reoxygenation (A/R)‐induced injury in H9c2 cells. 5-Hydroxydecanoate blocks the inhibitory effect of PHC on Ca2+ overload and ROS production. 5-Hydroxydecanoate promotes the release of Cyt-C from mitochondria into cytoplasm. 5-Hydroxydecanoate attenuats the anti-apoptotic effect of PHC. PHC treatment shows remarkably decreases levels of Bax and cleaved caspase-3, and increases levels of Bcl-2. 5-Hydroxydecanoate pretreatment reverses the effects of PHC on their expression levels. 5-Hydroxydecanoate blocks the effects of PHC on KATP channels[1]. |
| In Vivo | 5-Hydroxydecanoate (100 μM) treatment abolishes the effects of ischemic preconditioning (IPC) on the contractile recovery and does not affect its effect on the contracture, lactate production, glycogenolysis and viable tissue in rats[3]. |
| References |
| Boiling Point | 320.8ºC at 760 mmHg |
|---|---|
| Molecular Formula | C10H19NaO3 |
| Molecular Weight | 210.24600 |
| Flash Point | 162ºC |
| Exact Mass | 210.12300 |
| PSA | 60.36000 |
| LogP | 0.84780 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
|
CYP-epoxygenases contribute to A2A receptor-mediated aortic relaxation via sarcolemmal KATP channels.
Am. J. Physiol. Regul. Integr. Comp. Physiol. 303(10) , R1003-10, (2012) Previously, we have shown that A(2A) adenosine receptor (A(2A)AR) mediates aortic relaxation via cytochrome P-450 (CYP)-epoxygenases. However, the signaling mechanism is not understood properly. We hy... |
|
|
Is preconditioning by oxytocin administration mediated by iNOS and/or mitochondrial K(ATP) channel activation in the in vivo anesthetized rabbit heart?
Life Sci. 90(19-20) , 763-9, (2012) Oxytocin (OXT) pretreatment protects the heart during ischemia-reperfusion injury by activating ATP-dependent potassium (K(ATP)) channels. The aim of the current study was to elucidate the roles of ni... |
|
|
Mitochondrial K+ channels are involved in ischemic postconditioning in rat hearts.
J. Physiol. Sci. 62(4) , 325-32, (2012) The mitochondrial calcium-activated potassium channel (mitoK(Ca)) and the mitochondrial ATP-sensitive potassium channel (mitoK(ATP)) are both involved in cardiac preconditioning. Here, we examined whe... |
| 5-HYDROXYDECANOATE NA |
| Sodium 5-hydroxydecanoate |
| 5-HYDROXYDECANOIC ACID SODIUM |
| 5-Hydroxydecanoic acid sodium salt,5-hydroxydecanoate sodium salt |