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71186-53-3

71186-53-3 structure
71186-53-3 structure
  • Name: 5-Hydroxydecanoate sodium
  • Chemical Name: 5-hydroxydecanoic acid sodium salt
  • CAS Number: 71186-53-3
  • Molecular Formula: C10H19NaO3
  • Molecular Weight: 210.24600
  • Catalog: Signaling Pathways Membrane Transporter/Ion Channel Potassium Channel
  • Create Date: 2018-09-02 20:08:25
  • Modify Date: 2024-01-12 11:41:49
  • 5-Hydroxydecanoate sodium is a selective ATP-sensitive K+ (KATP) channel blocker (IC50 of ~30 μM). 5-Hydroxydecanoate sodium is a substrate for mitochondrial outer membrane acyl-CoA synthetase and has antioxidant activity[1][2].
Name 5-hydroxydecanoic acid sodium salt
Synonyms 5-HYDROXYDECANOATE NA
Sodium 5-hydroxydecanoate
5-HYDROXYDECANOIC ACID SODIUM
5-Hydroxydecanoic acid sodium salt,5-hydroxydecanoate sodium salt
Description 5-Hydroxydecanoate sodium is a selective ATP-sensitive K+ (KATP) channel blocker (IC50 of ~30 μM). 5-Hydroxydecanoate sodium is a substrate for mitochondrial outer membrane acyl-CoA synthetase and has antioxidant activity[1][2].
Related Catalog
Target

IC50: ~30 μM (KATP)

In Vitro 5-Hydroxydecanoate (5-HD) treatment abolishs the beneficial effects of penehyclidine hydrochloride (PHC) preconditioning in anoxia/reoxygenation (A/R)‐induced injury in H9c2 cells. 5-Hydroxydecanoate blocks the inhibitory effect of PHC on Ca2+ overload and ROS production. 5-Hydroxydecanoate promotes the release of Cyt-C from mitochondria into cytoplasm. 5-Hydroxydecanoate attenuats the anti-apoptotic effect of PHC. PHC treatment shows remarkably decreases levels of Bax and cleaved caspase-3, and increases levels of Bcl-2. 5-Hydroxydecanoate pretreatment reverses the effects of PHC on their expression levels. 5-Hydroxydecanoate blocks the effects of PHC on KATP channels[1].
In Vivo 5-Hydroxydecanoate (100 μM) treatment abolishes the effects of ischemic preconditioning (IPC) on the contractile recovery and does not affect its effect on the contracture, lactate production, glycogenolysis and viable tissue in rats[3].
References

[1]. Congna Zi, et al. Penehyclidine hydrochloride protects against anoxia/reoxygenation injury in cardiomyocytes through ATP-sensitive potassium channels, and the Akt/GSK-3β and Akt/mTOR signaling pathways. Cell Biol Int. 2020 Jun;44(6):1353-1362.

[2]. Xiantao Li, et al. 5-Hydroxydecanoate and coenzyme A are inhibitors of native sarcolemmal KATP channels in inside-out patches. Biochim Biophys Acta. 2010 Mar;1800(3):385-91.

[3]. M G Marina Prendes, et al. Effects of 5-hydroxydecanoate and ischemic preconditioning on the ischemic-reperfused heart of fed and fasted rats. J Physiol Biochem. 2005 Sep;61(3):447-56.
Boiling Point 320.8ºC at 760 mmHg
Molecular Formula C10H19NaO3
Molecular Weight 210.24600
Flash Point 162ºC
Exact Mass 210.12300
PSA 60.36000
LogP 0.84780
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport
WGK Germany 3

Chemsrc provides CAS#:71186-53-3 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 71186-53-3 | Chemsrc address: https://www.chemsrc.com/en/baike/402754.html

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