TC-1698

Modify Date: 2025-11-24 18:53:40

TC-1698 structure	Common Name	TC-1698
	CAS Number	700834-58-8	Molecular Weight	202.30
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₃H₁₈N₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of TC-1698

TC-1698 is a selective α7 nicotinic acetylcholine receptors agonist with EC50 value of 0.16 μM and 0.46 μM for monkey α7 nicotinic receptor and human α7 nicotinic receptor, respectively. TC-1698 improves memory and has neuroprotective effects. TC-1698 can be used for Alzheimer's disease research[1].

Name	2-pyridin-3-yl-1-azabicyclo[3.2.2]nonane

Description	TC-1698 is a selective α7 nicotinic acetylcholine receptors agonist with EC50 value of 0.16 μM and 0.46 μM for monkey α7 nicotinic receptor and human α7 nicotinic receptor, respectively. TC-1698 improves memory and has neuroprotective effects. TC-1698 can be used for Alzheimer's disease research[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR Signaling Pathways >> Neuronal Signaling >> nAChR Research Areas >> Neurological Disease
References	[1]. Mazurov AA, et al. Discovery and development of α7 nicotinic acetylcholine receptor modulators. J Med Chem. 2011 Dec 8;54(23):7943-61. [2]. Marrero MB, et al. The neuroprotective effect of 2-(3-pyridyl)-1-azabicyclo[3.2.2]nonane (TC-1698), a novel alpha7 ligand, is prevented through angiotensin II activation of a tyrosine phosphatase. J Pharmacol Exp Ther. 2004 Apr;309(1):16-27. [3]. Papke RL, et al. Rhesus monkey alpha7 nicotinic acetylcholine receptors: comparisons to human alpha7 receptors expressed in Xenopus oocytes. Eur J Pharmacol. 2005 Nov 7;524(1-3):11-8.

Description

Related Catalog

Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR

Signaling Pathways >> Neuronal Signaling >> nAChR

Research Areas >> Neurological Disease

References

[1]. Mazurov AA, et al. Discovery and development of α7 nicotinic acetylcholine receptor modulators. J Med Chem. 2011 Dec 8;54(23):7943-61.

[2]. Marrero MB, et al. The neuroprotective effect of 2-(3-pyridyl)-1-azabicyclo[3.2.2]nonane (TC-1698), a novel alpha7 ligand, is prevented through angiotensin II activation of a tyrosine phosphatase. J Pharmacol Exp Ther. 2004 Apr;309(1):16-27.

[3]. Papke RL, et al. Rhesus monkey alpha7 nicotinic acetylcholine receptors: comparisons to human alpha7 receptors expressed in Xenopus oocytes. Eur J Pharmacol. 2005 Nov 7;524(1-3):11-8.

Molecular Formula	C₁₃H₁₈N₂
Molecular Weight	202.30
Exact Mass	274.10000
PSA	16.13000
LogP	4.17040
InChIKey	WIEWCOLOPGXZDJ-UHFFFAOYSA-N
SMILES	c1cncc(C2CCC3CCN2CC3)c1

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: TC 1698 dihydrochloride
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Purity: 98.0%
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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.