Trifluorothymidine structure
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Common Name | Trifluorothymidine | ||
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CAS Number | 70-00-8 | Molecular Weight | 296.200 | |
Density | 1.6±0.1 g/cm3 | Boiling Point | N/A | |
Molecular Formula | C10H11F3N2O5 | Melting Point | 190-193 °C(lit.) | |
MSDS | Chinese USA | Flash Point | N/A | |
Symbol |
GHS07, GHS08 |
Signal Word | Warning |
Use of TrifluorothymidineTrifluridine is an irreversible thymidylate synthase inhibitor, and thereby suppresses DNA synthesis. Trifluridine is an antiviral drug for herpes simplex virus (HSV) infection. |
Name | trifluridine |
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Synonym | More Synonyms |
Description | Trifluridine is an irreversible thymidylate synthase inhibitor, and thereby suppresses DNA synthesis. Trifluridine is an antiviral drug for herpes simplex virus (HSV) infection. |
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Related Catalog | |
References |
Density | 1.6±0.1 g/cm3 |
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Melting Point | 190-193 °C(lit.) |
Molecular Formula | C10H11F3N2O5 |
Molecular Weight | 296.200 |
Exact Mass | 296.062012 |
PSA | 104.55000 |
LogP | 0.07 |
Index of Refraction | 1.534 |
Storage condition | −20°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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Symbol |
GHS07, GHS08 |
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Signal Word | Warning |
Hazard Statements | H302 + H312 + H332-H351 |
Precautionary Statements | P261-P280-P301 + P312 + P330 |
Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
Hazard Codes | Xi:Irritant |
Risk Phrases | R20/21/22;R40 |
Safety Phrases | S22-S36 |
RIDADR | NONH for all modes of transport |
WGK Germany | 3 |
RTECS | XP2087500 |
Precursor 8 | |
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DownStream 2 | |
Mechanistic evaluation of Ginkgo biloba leaf extract-induced genotoxicity in L5178Y cells.
Toxicol. Sci. 139(2) , 338-49, (2014) Ginkgo biloba has been used for many thousand years as a traditional herbal remedy and its extract has been consumed for many decades as a dietary supplement. Ginkgo biloba leaf extract is a complex m... |
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Quantitative high-throughput identification of drugs as modulators of human constitutive androstane receptor.
Sci. Rep. 5 , 10405, (2015) The constitutive androstane receptor (CAR, NR1I3) plays a key role in governing the transcription of numerous hepatic genes that involve xenobiotic metabolism/clearance, energy homeostasis, and cell p... |
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Differential activation of cell death and autophagy results in an increased cytotoxic potential for trifluorothymidine compared to 5-fluorouracil in colon cancer cells.
Int. J. Cancer 126 , 2457-2468, (2010) Trifluorothymidine (TFT) is part of the oral drug formulation TAS-102. Both 5-fluorouracil (5-FU) and TFT can inhibit thymidylate synthase and be incorporated into DNA. TFT shows only moderate cross-r... |
1-[(2R,4S,5R)-4-hydroxy-5-(hydroxyméthyl)tétrahydrofuran-2-yl]-5-(trifluorométhyl)pyrimidine-2,4(1H,3H)-dione |
Viroptic |
α,α,α-Trifluorothymidine |
2'-Deoxy-5-(trifluoromethyl)uridine |
UNII-RMW9V5RW38 |
Trifluorothymidine |
1-(2-Deoxy-β-D-glycero-pentofuranosyl)-5-(trifluoromethyl)pyrimidine-2,4(1H,3H)-dione |
Trifluridine |
1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-(trifluoromethyl)pyrimidine-2,4(1H,3H)-dione |
EINECS 200-722-8 |
1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-(trifluormethyl)pyrimidin-2,4(1H,3H)-dion |
2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-β-D-ribofuranosyl)-5-(trifluoromethyl)- |
2,4(1H,3H)-pyrimidinedione, 1-(2-deoxy-β-D-glycero-pentofuranosyl)-5-(trifluoromethyl)- |
2'-Deoxy-5-trifluoromethyluridine |
Virophta |
Uridine, 2'-deoxy-5-(trifluoromethyl)- |
a,a,a-Trifluorothymidine |
MFCD00006534 |