ZIO 101
Modify Date: 2025-08-25 10:16:33
ZIO 101 structure
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Common Name | ZIO 101 | ||
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| CAS Number | 69819-86-9 | Molecular Weight | 411.30600 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C12H22AsN3O6S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of ZIO 101Darinaparsin (ZIO-101), an organic arsenical, is a mitochondrial-targeted agent. Darinaparsin induces apoptosis in ancer cells, and has anticancer effects[1]. |
| Name | (2S)-2-amino-5-[[(2R)-1-(carboxymethylamino)-3-dimethylarsanylsulfanyl-1-oxopropan-2-yl]amino]-5-oxopentanoic acid |
|---|---|
| Synonym | More Synonyms |
| Description | Darinaparsin (ZIO-101), an organic arsenical, is a mitochondrial-targeted agent. Darinaparsin induces apoptosis in ancer cells, and has anticancer effects[1]. |
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| Related Catalog | |
| In Vitro | Darinaparsin is cytotoxic to prostate cancer cell lines as well as fresh prostate cancer cells at low micromolar concentrations, and importantly inhibits the termed tumor-initiating cells (TIC) subpopulations[1]. |
| In Vivo | Darinaparsin inhibits growth of the castrate-resistant Du145 prostate tumor propagated as xenograft in mice and inhibits the tumor-initiating potential of prostate cancer cells[1]. |
| References |
| Molecular Formula | C12H22AsN3O6S |
|---|---|
| Molecular Weight | 411.30600 |
| Exact Mass | 411.04500 |
| PSA | 191.10000 |
| LogP | 1.22930 |
| InChIKey | JGDXFQORBMPJGR-YUMQZZPRSA-N |
| SMILES | C[As](C)SCC(NC(=O)CCC(N)C(=O)O)C(=O)NCC(=O)O |
| Darinaparsin |
| ZIO-101-C |
| UNII-9XX54M675G |
| Zinapar |
| SGLU1 |
| ZIO-101 |
| SP-02L |
| Darinaparsin (USAN) |
| DMAs(III)G |