1370281-06-3
1370281-06-3 structure
- Name: FOBISIN 101
- Chemical Name: FOBISIN 101
- CAS Number: 1370281-06-3
- Molecular Formula: C15H11N3Na3O8P
- Molecular Weight: 461.209
- Create Date: 2020-01-19 22:39:56
- Modify Date: 2023-01-17 21:12:44
-
FOBISIN 101 is a small molecule 14-3-3 protein-protein interaction inhibitor with IC50 of 9.3 and 16.4 uM for the binding of 14-3-3ζ or 14-3-3γ to PRAS40, respectively; effectively blocks the ability of all seven 14-3-3 isoforms to stimulate exoenzyme S (ExoS) ADP-ribosyltransferase (IC50=6-19 uM in a functional assay); also blocked the binding of 14-3-3 with Raf-1 and proline-rich AKT substrate, PRAS40.
| Name | FOBISIN 101 |
|---|
| Description | FOBISIN 101 is a small molecule 14-3-3 protein-protein interaction inhibitor with IC50 of 9.3 and 16.4 uM for the binding of 14-3-3ζ or 14-3-3γ to PRAS40, respectively; effectively blocks the ability of all seven 14-3-3 isoforms to stimulate exoenzyme S (ExoS) ADP-ribosyltransferase (IC50=6-19 uM in a functional assay); also blocked the binding of 14-3-3 with Raf-1 and proline-rich AKT substrate, PRAS40. |
|---|---|
| References | References 1. Zhao J, et al. Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16212-6. 2. Du Y, et al. J Biomol Screen. 2006 Apr;11(3):269-76. 3. Fu H, et al. Proc Natl Acad Sci U S A. 1993 Mar 15;90(6):2320-4. View Related Products by Target 14-3-3 Protein |
| Molecular Formula | C15H11N3Na3O8P |
|---|---|
| Molecular Weight | 461.209 |