2-Bromoacetamide

Modify Date: 2024-01-02 11:19:15

2-Bromoacetamide Structure
2-Bromoacetamide structure
Common Name 2-Bromoacetamide
CAS Number 683-57-8 Molecular Weight 137.963
Density 1.8±0.1 g/cm3 Boiling Point 271.6±23.0 °C at 760 mmHg
Molecular Formula C2H4BrNO Melting Point 87-91 °C(lit.)
MSDS USA Flash Point 118.1±22.6 °C
Symbol GHS05 GHS06
GHS05, GHS06
Signal Word Danger

 Use of 2-Bromoacetamide


2-Bromoacetamide can inactivate alcohol dehydrogenase[1].

 Names

Name 2-Bromoacetamide
Synonym More Synonyms

 2-Bromoacetamide Biological Activity

Description 2-Bromoacetamide can inactivate alcohol dehydrogenase[1].
Related Catalog
References

[1]. Fries RW, et al. Activation of liver alcohol dehydrogenases by imidoesters generated in solution. Biochemistry. 1975;14(23):5233‐5238.

 Chemical & Physical Properties

Density 1.8±0.1 g/cm3
Boiling Point 271.6±23.0 °C at 760 mmHg
Melting Point 87-91 °C(lit.)
Molecular Formula C2H4BrNO
Molecular Weight 137.963
Flash Point 118.1±22.6 °C
Exact Mass 136.947617
PSA 43.09000
LogP -0.52
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.511
Storage condition Store at RT.

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AB4587000
CHEMICAL NAME :
Acetamide, 2-bromo-
CAS REGISTRY NUMBER :
683-57-8
BEILSTEIN REFERENCE NO. :
1739073
LAST UPDATED :
199612
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C2-H4-Br-N-O
MOLECULAR WEIGHT :
137.98
WISWESSER LINE NOTATION :
ZV1E

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
124 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YHTPAD Yaoxue Tongbao. Bulletin of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.13-23, 1978-88. For publisher information, see ZYZAEU. Volume(issue)/page/year: 16(8),54,1981
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
>102 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YHTPAD Yaoxue Tongbao. Bulletin of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.13-23, 1978-88. For publisher information, see ZYZAEU. Volume(issue)/page/year: 16(8),54,1981
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
61 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YHTPAD Yaoxue Tongbao. Bulletin of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.13-23, 1978-88. For publisher information, see ZYZAEU. Volume(issue)/page/year: 16(8),54,1981

 Safety Information

Symbol GHS05 GHS06
GHS05, GHS06
Signal Word Danger
Hazard Statements H301-H314
Precautionary Statements P280-P301 + P310-P305 + P351 + P338-P310
Personal Protective Equipment Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes T,C
Risk Phrases R25;R34
Safety Phrases S26-S27-S36/37/39-S45
RIDADR UN 2923 8/PG 2
WGK Germany 3
RTECS AB4587000
Packaging Group III
Hazard Class 8
HS Code 2924199013

 Synthetic Route

 Customs

HS Code 2924199013
Summary HS:2924199013 2-bromoacetamide VAT:17.0% Tax rebate rate:0.0% Supervision conditions:S MFN tariff:6.5% General tariff:30.0%

 Articles4

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Clinically there is a need for local anesthetics with a greater specificity of action on target cells and longer duration. We have synthesized a series of local anesthetic derivatives we call boronica...

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J. Med. Chem. 48(6) , 1745-58, (2005)

A series of ring-constrained (N)-methanocarba-5'-uronamide 2,N(6)-disubstituted adenine nucleosides have been synthesized via Mitsunobu condensation of the nucleobase precursor with a pseudosugar ring...

Kinetic analysis of sequence-specific alkylation of DNA by pyrimidine oligodeoxyribonucleotide-directed triple-helix formation.

Bioconjug. Chem. 8(3) , 354-64, (1997)

Attachment of a nondiffusible bromoacetyl electrophile to the 5-position of a thymine at the 5'-end of a pyrimidine oligodeoxyribonucleotide affords sequence-specific alkylation of a guanine base in d...

 Synonyms

Bromoacetamide
EINECS 226-270-1
Acetamide, 2-bromo-
MFCD00008025
2-Bromoacetamide
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